MIR1285-1 microRNA 1285-1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR1285-1provided by HGNC
Official Full Name: microRNA 1285-1provided by HGNC
Primary source: HGNC:HGNC:35277
See related: Ensembl:ENSG00000221520 miRBase:MI0006346; AllianceGenome:HGNC:35277
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN1285-1; hsa-mir-1285-1
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Annotation information: Note: MIR1285-1 (GeneID 100302218) was annotated incorrectly on NCBI's Build 37.2. Its correct location is chr7: 91833329-91833412 (-). [17 Jun 2014]
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Genomic context

Location:: 7q21.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (92204015..92204098, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (93445303..93445386, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (91833329..91833412, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Repression of Smad4 by MicroRNA-1285 moderates TGF-beta-induced epithelial-mesenchymal transition in proliferative vitreoretinopathy.
Title: Repression of Smad4 by MicroRNA-1285 moderates TGF-β-induced epithelial-mesenchymal transition in proliferative vitreoretinopathy.
Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.
Title: Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.
Data showed the tumor-suppressive role of miR-1285 and detailed its mechanism of action in breast cancer. Its overexpression significantly inhibited cell proliferation in breast cancer cells regardless of the tumor subtype. Also, miR-1285 was found to regulate TMEM194A expression by binding to its 3'-UTR.
Title: MiR-1285-5p/TMEM194A axis affects cell proliferation in breast cancer.
MiR-1285-3p was down regulated in osteosarcoma tissues and cell lines and reduction of miR-1285-3p expression predicted a poor overall survival of osteosarcoma patients. Ectopic expression of miR-1285-3p inhibited osteosarcoma cell proliferation, colony formation and invasion.
Title: miR-1285-3p is a potential prognostic marker in human osteosarcoma and functions as a tumor suppressor by targeting YAP1.
Methylation dependent microRNA 1285-5p and sterol carrier proteins 2 in type 2 diabetes mellitus
Title: Methylation dependent microRNA 1285-5p and sterol carrier proteins 2 in type 2 diabetes mellitus.
miR-1285 suppressed cell proliferation as well as increased the sensitivity of pancreatic ductal adenocarcinoma cells to gemcitabine; miR-1285 inhibited pancreatic cancer cell migration and invasion
Title: MicroRNA-1285 inhibits malignant biological behaviors of human pancreatic cancer cells by negative regulation of YAP1.
The combination of plasma miR-324-3p and miR-1285 could further improve the diagnostic accuracy of lung squamous cell carcinoma (LSCC).
Title: Plasma miR-324-3p and miR-1285 as diagnostic and prognostic biomarkers for early stage lung squamous cell carcinoma.
our data suggest that miR-1285-5p functions as a tumor promoter in the development of non-small-cell lung carcinoma by targeting Smad4 and CDH1, indicating a novel therapeutic strategy for non-small-cell lung carcinoma patients.
Title: MicroRNA-1285-5p influences the proliferation and metastasis of non-small-cell lung carcinoma cells via downregulating CDH1 and Smad4.
Data show that four cardiac fibroblast-derived microRNAS miR-660-3p, miR-665, miR-1285-3p and miR-4491 were found significantly upregulated in heart and plasma during heart failure.
Title: Identification of cardiac-related circulating microRNA profile in human chronic heart failure.
Human miR-1285-3p could directly repress JUN oncogene expression in hepatocellular carcinoma cells.
Title: miR-1285-3p acts as a potential tumor suppressor miRNA via downregulating JUN expression in hepatocellular carcinoma.

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Phenotypes

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Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.