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Grin1 glutamate ionotropic receptor NMDA type subunit 1 [ Cavia porcellus (domestic guinea pig) ]

Gene ID: 100301989, updated on 8-Mar-2024

Summary

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Gene symbol
Grin1
Gene description
glutamate ionotropic receptor NMDA type subunit 1
See related
Ensembl:ENSCPOG00000012581
Gene type
protein coding
RefSeq status
MODEL
Organism
Cavia porcellus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Also known as
nr1
Orthologs
human mouse all
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Genomic context

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See Grin1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947532.1 (180314..204044, complement)
103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176401.1 (38195708..38219430, complement)

NW_026947532.1Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 2 Neighboring gene transmembrane protein 210 Neighboring gene leucine rich repeat containing 26 Neighboring gene large ribosomal subunit protein eL36-like Neighboring gene mannosidase alpha class 1B member 1 Neighboring gene dipeptidyl peptidase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Upregulated expression of N-methyl-D-aspartate receptor 1 and nitric oxide synthase during form-deprivation myopia in guinea pigs. Wen D, et al. Int J Clin Exp Pathol, 2015. PMID 26097564, Free PMC Article
  2. Impact of protein kinase C activation on epileptiform activity in the hippocampal slice. Fuortes MG, et al. Epilepsy Res, 2008 Nov. PMID 18715754, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NMDA glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
glutamate receptor ionotropic, NMDA 1
Names
glutamate receptor NMDA 1
glutamate receptor, ionotropic, NMDA1 (zeta 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCavPor4.1

Genomic

  1. NW_026947532.1 Reference mCavPor4.1

    Range
    180314..204044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005005086.4 → XP_005005143.1  glutamate receptor ionotropic, NMDA 1 isoform X1

    Conserved Domains (6) summary
    cd06379
    Location:9 → 404
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:416 → 820
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:582 → 845
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42 → 378
    ANF_receptor; Receptor family ligand binding region
    pfam07885
    Location:623 → 677
    Ion_trans_2; Ion channel
    pfam10562
    Location:856 → 884
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

  2. XM_005005083.4 → XP_005005140.1  glutamate receptor ionotropic, NMDA 1 isoform X3

    Conserved Domains (6) summary
    cd06379
    Location:9 → 383
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:395 → 799
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:561 → 824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42 → 357
    ANF_receptor; Receptor family ligand binding region
    pfam07885
    Location:602 → 656
    Ion_trans_2; Ion channel
    pfam10562
    Location:835 → 863
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

  3. XM_003473098.5 → XP_003473146.1  glutamate receptor ionotropic, NMDA 1 isoform X8

    Conserved Domains (5) summary
    cd06379
    Location:9 → 383
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:395 → 799
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:561 → 824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42 → 357
    ANF_receptor; Receptor family ligand binding region
    pfam10562
    Location:835 → 863
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

  4. XM_023566388.2 → XP_023422156.1  glutamate receptor ionotropic, NMDA 1 isoform X7

    Conserved Domains (3) summary
    cd06379
    Location:9 → 383
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:395 → 799
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10562
    Location:835 → 863
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

  5. XM_005005084.4 → XP_005005141.1  glutamate receptor ionotropic, NMDA 1 isoform X4

    UniProtKB/TrEMBL
    A0A286XAB2
    Related
    ENSCPOP00000022370.1
    Conserved Domains (5) summary
    cd06379
    Location:9 → 383
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:395 → 799
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:561 → 824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42 → 357
    ANF_receptor; Receptor family ligand binding region
    pfam10562
    Location:835 → 863
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

  6. XM_003473097.5 → XP_003473145.1  glutamate receptor ionotropic, NMDA 1 isoform X6

    UniProtKB/TrEMBL
    A0A286Y484
    Related
    ENSCPOP00000032373.1
    Conserved Domains (5) summary
    cd06379
    Location:9 → 404
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:416 → 820
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:582 → 845
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42 → 378
    ANF_receptor; Receptor family ligand binding region
    pfam10562
    Location:856 → 884
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

  7. XM_023566387.2 → XP_023422155.1  glutamate receptor ionotropic, NMDA 1 isoform X5

    UniProtKB/TrEMBL
    H0VLR5
    Related
    ENSCPOP00000011318.3
    Conserved Domains (4) summary
    cd06379
    Location:9 → 404
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:416 → 820
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam07885
    Location:622 → 677
    Ion_trans_2; Ion channel
    pfam10562
    Location:856 → 884
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

  8. XM_003473099.5 → XP_003473147.1  glutamate receptor ionotropic, NMDA 1 isoform X2

    UniProtKB/TrEMBL
    A0A286XML8
    Related
    ENSCPOP00000026544.1
    Conserved Domains (5) summary
    cd06379
    Location:9 → 404
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:416 → 820
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:582 → 845
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42 → 378
    ANF_receptor; Receptor family ligand binding region
    pfam10562
    Location:856 → 884
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
Nucleotide Protein
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