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Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 100301568, updated on 17-Aug-2024

Summary

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Official Symbol
Aboprovided by RGD
Official Full Name
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferaseprovided by RGD
Primary source
RGD:2307241
See related
EnsemblRapid:ENSRNOG00000086621 AllianceGenome:RGD:2307241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Abo2
Summary
Enables alpha-1,3-galactosyltransferase activity and glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in several processes, including cellular oligosaccharide metabolic process; response to nematode; and response to retinoic acid. Located in Golgi apparatus and cytoplasmic vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; gallbladder carcinoma; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 37.7), Heart (RPKM 31.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Abo in Genome Data Viewer
Location:
3p13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30560172..30604758, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10162087..10182835, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (4374679..4394374, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S13, pseudogene 10 Neighboring gene lipocalin 4-like 1 Neighboring gene endosulfine alpha, pseudogene 1 Neighboring gene surfeit 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The clinical implications of ABO blood groups in Pseudomonas aeruginosa sepsis in children. Kuo KC, et al. J Microbiol Immunol Infect, 2013 Apr. PMID 22464692
  2. [Clinical efficacies of ABO-incompatible adult liver transplantation]. Ju WQ, et al. Zhonghua Yi Xue Za Zhi, 2011 Sep 27. PMID 22321886
  3. Distribution of ABO blood groups in childhood acute leukemia. Alavi S, et al. Pediatr Hematol Oncol, 2006 Dec. PMID 17065136
  4. Influence of infectious diseases on hereditary polymorphism with respect to the blood groups of the ABO system. Bubnov YI, et al. Sov Genet, 1974 Nov 15. PMID 4375858
  5. ABO compatibility and acute graft-versus-host disease following allogeneic bone marrow transplantation. Bacigalupo A, et al. Transplantation, 1988 Jun. PMID 3289150

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-1,3-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables fucosylgalactoside 3-alpha-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nematode IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histo-blood group ABO system transferase 2
Names
ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase)
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
NAGAT 2
a transferase
b blood group galactosyltransferase
b transferase
blood group A glycosyltransferase 2
cis-AB transferase 2
fucosylglycoprotein 3-alpha-galactosyltransferase
fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
glycoprotein-fucosylgalactoside alpha-galactosyltransferase
histo-blood group A transferase
histo-blood group B transferase
putative blood group A transferase T2
transferase B, alpha 1-3-galactosyltransferase)
NP_001153735.1
XP_038960003.1
XP_063139013.1
XP_063139014.1
XP_063139015.1
XP_063139016.1
XP_063139017.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160263.2 → NP_001153735.1  histo-blood group ABO system transferase 2

    See identical proteins and their annotated locations for NP_001153735.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q8CFC4
    UniProtKB/TrEMBL
    A6JTH9
    Related
    ENSRNOP00000091204.2, ENSRNOT00000099183.2
    Conserved Domains (1) summary
    pfam03414
    Location:47 → 334
    Glyco_transf_6; Glycosyltransferase family 6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    30560172..30604758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282943.1 → XP_063139013.1  histo-blood group ABO system transferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y5Y8
    Related
    ENSRNOP00000077138.2, ENSRNOT00000115517.2

  2. XM_063282945.1 → XP_063139015.1  histo-blood group ABO system transferase 2 isoform X2

  3. XM_063282946.1 → XP_063139016.1  histo-blood group ABO system transferase 2 isoform X2

  4. XM_039104075.2 → XP_038960003.1  histo-blood group ABO system transferase 2 isoform X2

    Conserved Domains (1) summary
    cl11394
    Location:1 → 212
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  5. XM_063282947.1 → XP_063139017.1  histo-blood group ABO system transferase 2 isoform X2

  6. XM_063282944.1 → XP_063139014.1  histo-blood group ABO system transferase 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFC4.1 GenPept UniProtKB/Swiss-Prot:Q8CFC4

Gene LinkOut

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