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GNG12-AS1 GNG12, DIRAS3 and WLS antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 100289178, updated on 10-Oct-2023

Summary

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Official Symbol
GNG12-AS1provided by HGNC
Official Full Name
GNG12, DIRAS3 and WLS antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:43938
See related
Ensembl:ENSG00000232284 MIM:615406; AllianceGenome:HGNC:43938
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in gall bladder (RPKM 1.2), prostate (RPKM 1.1) and 24 other tissues See more
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Genomic context

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See GNG12-AS1 in Genome Data Viewer
Location:
1p31.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (67832288..68202987)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (67709732..68080405)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (68297971..68668670)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 984 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:68151855-68153054 Neighboring gene Sharpr-MPRA regulatory region 15496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:68174006-68174506 Neighboring gene Sharpr-MPRA regulatory region 6234 Neighboring gene growth arrest and DNA damage inducible alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1183 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:68211594-68212415 Neighboring gene uncharacterized LOC105378781 Neighboring gene G protein subunit gamma 12 Neighboring gene Sharpr-MPRA regulatory region 6160 Neighboring gene RNA, U7 small nuclear 80 pseudogene Neighboring gene Sharpr-MPRA regulatory region 9183 Neighboring gene uncharacterized LOC124900403 Neighboring gene sirtuin 5 pseudogene Neighboring gene ARL5A pseudogene 3 Neighboring gene DIRAS family GTPase 3 Neighboring gene Sharpr-MPRA regulatory region 5584 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:68613408-68614607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:68627528-68628104 Neighboring gene Wnt ligand secretion mediator Neighboring gene NANOG hESC enhancer GRCh37_chr1:68665327-68665828 Neighboring gene CTBP2 pseudogene 8 Neighboring gene microRNA 1262 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:68742024-68742651 Neighboring gene NANOG hESC enhancer GRCh37_chr1:68743733-68744317 Neighboring gene ribosomal protein S7 pseudogene 4 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3β/β-catenin pathway. Xiang Z, et al. Biosci Rep, 2020 Aug 28. PMID 32735016, Free PMC Article
  2. Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions. Stojic L, et al. Nat Commun, 2016 Feb 2. PMID 26832224, Free PMC Article
  3. Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA. Niemczyk M, et al. Am J Hum Genet, 2013 Aug 8. PMID 23871723, Free PMC Article
  4. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Zhang L, et al. Hum Mol Genet, 2014 Apr 1. PMID 24249740, Free PMC Article
  5. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Rivadeneira F, et al. Nat Genet, 2009 Nov. PMID 19801982, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3beta/beta-catenin pathway.
    Title: Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3β/β-catenin pathway.
  2. This study showed that while most siRNAs silence GNG12-AS1 post-transcriptionally, siRNA complementary to exon 1 of GNG12-AS1 suppresses its transcription by recruiting Argonaute 2 and inhibiting RNA polymerase II binding.
    Title: Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
EBI GWAS Catalog
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • GNG12 antisense RNA 1 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_040077.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK124028, AL513284, DB291468
    Related
    ENST00000420587.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    67832288..68202987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    67709732..68080405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials