NANOG Nanog homeobox [Gallus gallus (chicken)] - Gene

Summary

Symbol: NANOGprovided by CGNC
Full Name: Nanog homeoboxprovided by CGNC
Primary source: CGNC:59260
See related: Ensembl:ENSGALG00010021471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (75876512..75881095, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (76087819..76092409, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that moderate regulation of Nanog homeobox protein (NANOG) by the REST/CoREST/HDAC complex might be crucial for maintaining the integrity of primordial germ cells (PGCs)
Title: Role of Epigenetic Regulation by the REST/CoREST/HDAC Corepressor Complex of Moderate NANOG Expression in Chicken Primordial Germ Cells.
NANOG Is Required for the Long-Term Establishment of Avian Somatic Reprogrammed Cells.
Title: NANOG Is Required for the Long-Term Establishment of Avian Somatic Reprogrammed Cells.
results demonstrate that the CTD of cNANOG belongs to a novel IDP that switches into a helical oligomer via self-association, enabling the maintenance of PGCs and blastoderm cells.
Title: Chicken NANOG self-associates via a novel folding-upon-binding mechanism.
Data indicate that cultured embryonic stem cells (cESCs) expressed pluripotency transcription factors, POUV, Sox-2, Nanog and Lin28 exhibited typical characteristics of pluripotency, even after six generations of rapid doubling.
Title: Four recombinant pluripotency transcriptional factors containing a protein transduction domain maintained the in vitro pluripotency of chicken embryonic stem cells.
Activin/TGF-beta signaling regulates Nanog expression in the epiblast during gastrulation
Title: Activin/TGF-beta signaling regulates Nanog expression in the epiblast during gastrulation.
Stduies indicate that Oct4 and Nanog genes were involved in the characterization and maintenance of the chicken pluripotency.
Title: Chicken embryonic stem cells as a non-mammalian embryonic stem cell model.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: homeobox protein NANOG

Names: cNanog; homeobox transcription factor Nanog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146142.2 → NP_001139614.1 homeobox protein NANOG

See identical proteins and their annotated locations for NP_001139614.1

Status: VALIDATED

Source sequence(s)

JAENSK010000015

UniProtKB/Swiss-Prot

A7Y7W3, R4GLF7

Related

ENSGALP00010031072.1, ENSGALT00010052054.1

Conserved Domains (1) summary

pfam00046
Location:101 → 154

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

75876512..75881095 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

76087819..76092409 complement

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GenBank, FASTA, Sequence Viewer (Graphics)