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PLCG2 phospholipase C gamma 2 [ Taeniopygia guttata (zebra finch) ]

Gene ID: 100219388, updated on 13-Aug-2024

Summary

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Gene symbol
PLCG2
Gene description
phospholipase C gamma 2
See related
Ensembl:ENSTGUG00000004405
Gene type
protein coding
RefSeq status
MODEL
Organism
Taeniopygia guttata
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves; Passeriformes; Passeroidea; Estrildidae; Estrildinae; Taeniopygia
Orthologs
human mouse all
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Genomic context

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See PLCG2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
34
Annotation release Status Assembly Chr Location
106 current bTaeGut1.4.pri (GCF_003957565.2) 11 NC_044223.2 (7915605..7971218)
105 previous assembly bTaeGut2.pat.W.v2 (GCF_008822105.2) 11 NC_045010.1 (16514278..16569779)

Chromosome 11 - NC_044223.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115496836 Neighboring gene c-Maf inducing protein Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene hydroxysteroid 17-beta dehydrogenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Taeniopygia guttata Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bTaeGut1.4.pri Primary Assembly

Genomic

  1. NC_044223.2 Reference bTaeGut1.4.pri Primary Assembly

    Range
    7915605..7971218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030282263.3 → XP_030138123.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

    UniProtKB/TrEMBL
    A0A674G937
    Related
    ENSTGUP00000019040.1
    Conserved Domains (10) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08628
    Location:311 → 458
    PI-PLCc_gamma2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma2
    cd09932
    Location:642 → 745
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 628
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840 → 909
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:23 → 139
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:924 → 1031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:477 → 512
    PH-like; Pleckstrin homology-like domain

  2. XM_030282264.3 → XP_030138124.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2

    UniProtKB/TrEMBL
    A0A674G937, H0Z1Z9
    Related
    ENSTGUP00000004589.2
    Conserved Domains (9) summary
    cd00275
    Location:1019 → 1145
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08628
    Location:269 → 416
    PI-PLCc_gamma2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma2
    cd09932
    Location:600 → 703
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:485 → 586
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:731 → 785
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:798 → 867
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd16215
    Location:103 → 256
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:882 → 989
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:25 → 97
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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