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AGRN agrin [ Taeniopygia guttata (zebra finch) ]

Gene ID: 100219336, updated on 13-Aug-2024

Summary

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Gene symbol
AGRN
Gene description
agrin
See related
Ensembl:ENSTGUG00000004020
Gene type
protein coding
RefSeq status
MODEL
Organism
Taeniopygia guttata
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves; Passeriformes; Passeroidea; Estrildidae; Estrildinae; Taeniopygia
Orthologs
human mouse all
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Genomic context

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See AGRN in Genome Data Viewer
Location:
chromosome: 21
Exon count:
42
Annotation release Status Assembly Chr Location
106 current bTaeGut1.4.pri (GCF_003957565.2) 21 NC_044233.2 (127184..185116, complement)
105 previous assembly bTaeGut2.pat.W.v2 (GCF_008822105.2) 21 NC_045019.1 (111520..169930, complement)

Chromosome 21 - NC_044233.2Genomic Context describing neighboring genes Neighboring gene chromosome 21 C1orf159 homolog Neighboring gene ring finger protein 223 Neighboring gene uncharacterized LOC116809208 Neighboring gene uncharacterized LOC116809207

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor clustering IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
agrin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Taeniopygia guttata Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bTaeGut1.4.pri Primary Assembly

Genomic

  1. NC_044233.2 Reference bTaeGut1.4.pri Primary Assembly

    Range
    127184..185116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041720422.1 → XP_041576356.1  agrin isoform X4

    UniProtKB/TrEMBL
    H0Z0S3
    Conserved Domains (8) summary
    smart00280
    Location:557 → 602
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1146 → 1268
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00282
    Location:1948 → 2081
    LamG; Laminin G domain
    PHA03378
    Location:1285 → 1355
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:1858 → 1890
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:793 → 834
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1410 → 1560
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  2. XM_041720420.1 → XP_041576354.1  agrin isoform X2

    UniProtKB/TrEMBL
    H0Z0S3
    Conserved Domains (8) summary
    smart00280
    Location:564 → 609
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1153 → 1275
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00282
    Location:1955 → 2088
    LamG; Laminin G domain
    PHA03378
    Location:1292 → 1362
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:1865 → 1897
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:800 → 841
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00104
    Location:430 → 470
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1417 → 1567
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  3. XM_041720421.1 → XP_041576355.1  agrin isoform X3

    UniProtKB/TrEMBL
    H0Z0S3
    Conserved Domains (8) summary
    smart00280
    Location:564 → 609
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1153 → 1275
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00282
    Location:1951 → 2084
    LamG; Laminin G domain
    PHA03378
    Location:1292 → 1362
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:1861 → 1893
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:800 → 841
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00104
    Location:430 → 470
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1417 → 1567
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  4. XM_041720423.1 → XP_041576357.1  agrin isoform X5

    UniProtKB/TrEMBL
    A0A674H9J1
    Conserved Domains (7) summary
    smart00280
    Location:564 → 609
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1153 → 1275
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    PHA03378
    Location:1292 → 1362
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:1865 → 1897
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:800 → 841
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00104
    Location:430 → 470
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1417 → 1567
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  5. XM_041720419.1 → XP_041576353.1  agrin isoform X1

    UniProtKB/TrEMBL
    H0Z0S3
    Conserved Domains (8) summary
    smart00280
    Location:564 → 609
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1153 → 1275
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00282
    Location:1955 → 2088
    LamG; Laminin G domain
    PHA03378
    Location:1292 → 1362
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:1865 → 1897
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:800 → 841
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00104
    Location:430 → 470
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1417 → 1567
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  6. XM_041720424.1 → XP_041576358.1  agrin isoform X6

    UniProtKB/TrEMBL
    A0A674HUH7
    Conserved Domains (7) summary
    smart00280
    Location:564 → 609
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1153 → 1275
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    PHA03378
    Location:1292 → 1362
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:1865 → 1897
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:800 → 841
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00104
    Location:430 → 470
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1417 → 1567
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  7. XM_030289462.3 → XP_030145322.3  agrin isoform X7

    UniProtKB/TrEMBL
    A0A674HJW5
    Conserved Domains (8) summary
    smart00280
    Location:455 → 500
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1044 → 1166
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00282
    Location:1846 → 1979
    LamG; Laminin G domain
    PHA03378
    Location:1183 → 1253
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:1756 → 1788
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:691 → 732
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00104
    Location:321 → 361
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1308 → 1458
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  8. XM_030289463.3 → XP_030145323.3  agrin isoform X8

    UniProtKB/TrEMBL
    A0A674HJW5
    Conserved Domains (8) summary
    smart00280
    Location:455 → 500
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1044 → 1166
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    PHA03378
    Location:1183 → 1253
    PHA03378; EBNA-3B; Provisional
    PRK07764
    Location:895 → 1018
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00054
    Location:1756 → 1788
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:691 → 732
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00104
    Location:321 → 361
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1308 → 1458
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
Nucleotide Protein
Heading Accession and Version

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