eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: eif2ak4provided by Xenbase
Official Full Name: eukaryotic translation initiation factor 2 alpha kinase 4provided by Xenbase
Primary source: Xenbase:XB-GENE-967321
See related: Ensembl:ENSXETG00000002204 AllianceGenome:Xenbase:XB-GENE-967321
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable ATP binding activity; eukaryotic translation initiation factor 2alpha kinase activity; and histone H2AS1 kinase activity. Predicted to act upstream of or within DNA damage checkpoint signaling and regulation of translational initiation by eIF2 alpha phosphorylation. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease 2. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (107784120..107825330)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (87508325..87549574)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translational initiation by eIF2 alpha phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eIF-2-alpha kinase GCN2

Names: GCN2 protein

NP_001243855.1

EC 2.7.11.1

XP_012823581.1

EC 2.7.11.1

XP_012823582.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256926.2 → NP_001243855.1 eIF-2-alpha kinase GCN2

Status: PROVISIONAL

Source sequence(s)

AAMC04000008, CX847035

UniProtKB/TrEMBL

A0A6I8SZS2, A0A8J0QES6

Related

ENSXETP00000099669.2, ENSXETT00000100921.2

Conserved Domains (8) summary

smart00220
Location:607 → 1017

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0124
Location:1081 → 1511

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd14012
Location:316 → 555

PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

cd14046
Location:600 → 1019

STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

pfam00069
Location:305 → 556

Pkinase; Protein kinase domain

pfam05773
Location:33 → 142

RWD; RWD domain

cl00266
Location:1416 → 1607

HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

cl00268
Location:1081 → 1408

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

107784120..107825330

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012968127.3 → XP_012823581.1 eIF-2-alpha kinase GCN2 isoform X1

UniProtKB/TrEMBL

A0A6I8QNC7, A0A6I8SZS2

Related

ENSXETP00000071118.2, ENSXETT00000094898.2

Conserved Domains (8) summary

smart00220
Location:607 → 1023

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0124
Location:1087 → 1517

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd14012
Location:316 → 555

PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

cd14046
Location:600 → 1025

STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

pfam00069
Location:305 → 556

Pkinase; Protein kinase domain

pfam05773
Location:33 → 142

RWD; RWD domain

cl00266
Location:1422 → 1613

HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

cl00268
Location:1087 → 1414

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
XM_012968128.3 → XP_012823582.1 eIF-2-alpha kinase GCN2 isoform X2

UniProtKB/TrEMBL

A0A6I8PUU9, A0A6I8SZS2

Related

ENSXETP00000058997.2, ENSXETT00000066083.3

Conserved Domains (4) summary

PLN02972
Location:1089 → 1507

PLN02972; Histidyl-tRNA synthetase

cd14012
Location:316 → 555

PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

cd14046
Location:600 → 1014

STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

pfam05773
Location:35 → 142

RWD; RWD domain