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cxcr4.L C-X-C motif chemokine receptor 4 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100192360, updated on 4-Nov-2024

Summary

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Official Symbol
cxcr4.L
Official Full Name
C-X-C motif chemokine receptor 4 L homeolog
Primary source
Xenbase:XB-GENE-489921
Locus tag
XELAEV_18044533mg
See related
AllianceGenome:Xenbase:XB-GENE-489921
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fb22; hm89; lap3; lcr1; npyr; cd184; cxcr4; lestr; npy3r; npyrl; hsy3rr; npyy3r; xCXCR4; cxcr4-a; cxcr4-b; CXC-R4-A; CXCR-4-A
Summary
Enables C-X-C chemokine receptor activity. Acts upstream of or within several processes, including definitive hemopoiesis; germ cell migration; and mesoderm migration involved in gastrulation. Located in cytoplasm and nucleus. Is expressed in dermal system; ectoderm; nervous system; and visual system. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See cxcr4.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
2
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (63711637..63715059, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (53185755..53189231, complement)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance complex component 6 L homeolog Neighboring gene aspartyl-tRNA synthetase 1 L homeolog Neighboring gene thrombospondin type 1 domain containing 7B L homeolog Neighboring gene uncharacterized LOC121398015 Neighboring gene histamine N-methyltransferase L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mode and molecular mechanisms of the migration of presumptive PGC in the endoderm cell mass of Xenopus embryos. Nishiumi F, et al. Dev Growth Differ, 2005 Jan. PMID 15740585
  2. Xenopus laevis Stromal cell-derived factor 1: conservation of structure and function during vertebrate development. Braun M, et al. J Immunol, 2002 Mar 1. PMID 11859124
  3. Characterization of a Xenopus laevis CXC chemokine receptor 4: implications for hematopoietic cell development in the vertebrate embryo. Moepps B, et al. Eur J Immunol, 2000 Oct. PMID 11069075
  4. Expression of xSDF-1α, xCXCR4, and xCXCR7 during gastrulation in Xenopus laevis. Mishra SK, et al. Int J Dev Biol, 2013. PMID 23585357
  5. SDF-1 alpha regulates mesendodermal cell migration during frog gastrulation. Fukui A, et al. Biochem Biophys Res Commun, 2007 Mar 9. PMID 17239342

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82907

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables C-C chemokine binding IEA
Inferred from Electronic Annotation
more info
  
enables C-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables C-X-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brain development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within definitive hemopoiesis IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within gastrulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within germ cell migration IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mesoderm migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neurogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
C-X-C chemokine receptor type 4-A
Names
SDF-1 receptor-A
Stromal cell-derived factor 1 receptor-A
chemokine (C-X-C motif) receptor 4 L homeolog
chemokine receptor 4
stromal cell-derived factor 1 receptor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137581.1 → NP_001131053.1  C-X-C chemokine receptor type 4-A

    See identical proteins and their annotated locations for NP_001131053.1

    Status: PROVISIONAL

    Source sequence(s)
    BC073603
    UniProtKB/Swiss-Prot
    Q9YGC3
    Conserved Domains (2) summary
    pfam00001
    Location:59 → 309
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam12109
    Location:10 → 42
    CXCR4_N; CXCR4 Chemokine receptor N terminal

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    63711637..63715059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9YGC3.1 GenPept UniProtKB/Swiss-Prot:Q9YGC3

Gene LinkOut

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