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itga2b.S integrin subunit alpha 2b S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100191022, updated on 4-Nov-2024

Summary

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Official Symbol
itga2b.S
Official Full Name
integrin subunit alpha 2b S homeolog
Primary source
Xenbase:XB-GENE-1009581
Locus tag
XELAEV_18046044mg
See related
EnsemblRapid:ENSXLAG00005032468 AllianceGenome:Xenbase:XB-GENE-1009581
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
gta; cd41; gp2b; hpa3; cd41b; gpiib; itga2b.1; itga2b.1.S
Summary
Predicted to enable integrin binding activity. Predicted to act upstream of or within several processes, including angiogenesis; cell adhesion mediated by integrin; and integrin-mediated signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be part of integrin complex. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See itga2b.S in Genome Data Viewer
Location:
chromosome: 9_10S
Exon count:
33
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (4720065..4736499)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (4591717..4608971)

Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121398987 Neighboring gene G-patch domain containing 8 S homeolog Neighboring gene family with sequence similarity 171 member A2 S homeolog Neighboring gene uncharacterized LOC121399157

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integrin alpha subunit mRNAs are differentially expressed in early Xenopus embryos. Whittaker CA, et al. Development, 1993 Apr. PMID 8404528
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC80695

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin subunit alpha 2b S homeolog
Names
integrin alpha V-like subunit
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136171.1 → NP_001129643.1  integrin subunit alpha 2b S homeolog precursor

    See identical proteins and their annotated locations for NP_001129643.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077891
    UniProtKB/TrEMBL
    A0A974BSM0, Q6DCU9
    Related
    ENSXLAP00005097646.1, ENSXLAT00005099442.1
    Conserved Domains (3) summary
    smart00191
    Location:362 → 416
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:459 → 913
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:255 → 318
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    4720065..4736499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041577604.1 → XP_041433538.1  integrin subunit alpha 2b S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8EL13, A0A974BSB8, A0A974BSM0
    Related
    ENSXLAP00005098072.1, ENSXLAT00005099879.1
    Conserved Domains (3) summary
    smart00191
    Location:362 → 416
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:459 → 913
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:255 → 318
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  2. XM_018237132.2 → XP_018092621.1  integrin subunit alpha 2b S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8EL13, A0A974BSB8, A0A974BSM0
    Related
    ENSXLAP00005097944.1, ENSXLAT00005099751.1
    Conserved Domains (3) summary
    smart00191
    Location:362 → 416
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:459 → 913
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:255 → 318
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  3. XM_041577605.1 → XP_041433539.1  integrin subunit alpha 2b S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8EL13, A0A974BSB8, A0A974BSM0
    Related
    ENSXLAP00005097813.1, ENSXLAT00005099620.1
    Conserved Domains (3) summary
    smart00191
    Location:362 → 416
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:459 → 913
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:255 → 318
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Nucleotide Protein Strain
Heading Accession and Version

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