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ptch2.L patched 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100191013, updated on 4-Nov-2024

Summary

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Official Symbol
ptch2.L
Official Full Name
patched 2 L homeolog
Primary source
Xenbase:XB-GENE-1033872
Locus tag
XELAEV_18023085mg
See related
EnsemblRapid:ENSXLAG00005031482 AllianceGenome:Xenbase:XB-GENE-1033872
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ptc2; ptc-2; ptch2; xptc-2; ptch2-a; ptch2-b; Xptch-2'; patched-2
Summary
Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Predicted to act upstream of or within negative regulation of smoothened signaling pathway. Predicted to be located in plasma membrane. Is expressed in anatomical system; appendage; ectoderm; mesenchyme; and pharyngeal arch. Human ortholog(s) of this gene implicated in basal cell carcinoma and medulloblastoma. Orthologous to human PTCH2 (patched 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ptch2.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
24
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (85712289..85741083)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (80415071..80443918)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108714273 Neighboring gene eukaryotic translation initiation factor 2B subunit gamma L homeolog Neighboring gene BTB/POZ domain-containing protein 19-like Neighboring gene uncharacterized LOC121403048 Neighboring gene polo-like kinase 3 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct expression of two types of Xenopus Patched genes during early embryogenesis and hindlimb development. Takabatake T, et al. Mech Dev, 2000 Nov. PMID 11044611
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC79874

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables hedgehog family protein binding IEA
Inferred from Electronic Annotation
more info
  
enables hedgehog receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables smoothened binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
patched 2 L homeolog
Names
patched homolog 2
xptc 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136166.1 → NP_001129638.1  patched 2 L homeolog

    See identical proteins and their annotated locations for NP_001129638.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070995
    UniProtKB/TrEMBL
    A0A974D5D7, Q6IRA5
    Related
    ENSXLAP00005094451.1, ENSXLAT00005096153.1
    Conserved Domains (2) summary
    TIGR00918
    Location:26 → 1172
    2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
    pfam12349
    Location:443 → 593
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    85712289..85741083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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