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ERV3-1 endogenous retrovirus group 3 member 1, envelope [ Pan troglodytes (chimpanzee) ]

Gene ID: 100190893, updated on 3-Apr-2024

Summary

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Gene symbol
ERV3-1
Gene description
endogenous retrovirus group 3 member 1, envelope
Locus tag
CK820_G0050102
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as
ERV3; envR; HERV-R
Summary
Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene is expressed at a higher level in the adrenal cortex and placenta and may play a role in human physiology and disease. [provided by RefSeq, Jun 2015]
Orthologs
human all
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Genomic context

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See ERV3-1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 6 NC_072404.2 (72548221..72564518, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 7 NC_072405.1 (69645491..69663268, complement)

Chromosome 6 - NC_072404.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107976138 Neighboring gene vomeronasal 1 receptor panTroV1R-ps232 pseudogene Neighboring gene zinc finger protein 85-like Neighboring gene uncharacterized LOC107971917 Neighboring gene uncharacterized LOC129135484 Neighboring gene U6 spliceosomal RNA Neighboring gene T-complex protein 1 subunit zeta-like Neighboring gene small nucleolar RNA SNORA22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Human Endogenous Retrovirus (HERV)-R family in primates: Chromosomal location, gene expression, and evolution. Kim HS, et al. Gene, 2006 Mar 29. PMID 16443335
  2. Comprehensive search for intra- and inter-specific sequence polymorphisms among coding envelope genes of retroviral origin found in the human genome: genes and pseudogenes. de Parseval N, et al. BMC Genomics, 2005 Sep 9. PMID 16150157, Free PMC Article
  3. Conservation and loss of the ERV3 open reading frame in primates. Hervé CA, et al. Genomics, 2004 May. PMID 15081124

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

General protein information

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Preferred Names
endogenous retrovirus group 3 member 1 Env polyprotein
Names
HERV-R env
endogenous retroviral sequence 3
endogenous retrovirus group 3, member 1
endogenous retrovirus proviral envR
envelope protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135588.1 → NP_001129060.1  endogenous retrovirus group 3 member 1 Env polyprotein precursor

    See identical proteins and their annotated locations for NP_001129060.1

    Status: REVIEWED

    Source sequence(s)
    AJ862651
    UniProtKB/TrEMBL
    Q4W2L3
    Conserved Domains (1) summary
    cd09850
    Location:521 → 597
    Ebola-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    72548221..72564518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016956774.4 → XP_016812263.2  endogenous retrovirus group 3 member 1 Env polyprotein isoform X1

    UniProtKB/TrEMBL
    A0A2J8J7F2, A0A8I3B0P3, K7ABB3, K7CEJ0
    Conserved Domains (2) summary
    cd09850
    Location:521 → 597
    Ebola-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains
    pfam00429
    Location:413 → 583
    TLV_coat; ENV polyprotein (coat polyprotein)

  2. XM_054687026.2 → XP_054543001.1  endogenous retrovirus group 3 member 1 Env polyprotein isoform X1

    UniProtKB/TrEMBL
    A0A2J8J7F2, A0A8I3B0P3, K7ABB3, K7CEJ0

  3. XM_063813731.1 → XP_063669801.1  endogenous retrovirus group 3 member 1 Env polyprotein isoform X1

    UniProtKB/TrEMBL
    A0A2J8J7F2, A0A8I3B0P3, K7ABB3, K7CEJ0

  4. XM_024357564.3 → XP_024213332.1  endogenous retrovirus group 3 member 1 Env polyprotein isoform X1

    UniProtKB/TrEMBL
    A0A2J8J7F2, A0A8I3B0P3, K7ABB3, K7CEJ0
    Conserved Domains (2) summary
    cd09850
    Location:521 → 597
    Ebola-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains
    pfam00429
    Location:413 → 583
    TLV_coat; ENV polyprotein (coat polyprotein)
Nucleotide Protein
Heading Accession and Version

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