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TOMM6 translocase of outer mitochondrial membrane 6 [ Homo sapiens (human) ]

Gene ID: 100188893, updated on 8-Mar-2024

Summary

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Official Symbol
TOMM6provided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 6provided by HGNC
Primary source
HGNC:HGNC:34528
See related
Ensembl:ENSG00000214736 MIM:616168; AllianceGenome:HGNC:34528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBTP; TOM6
Summary
Predicted to be involved in protein transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 63.4), kidney (RPKM 57.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p21.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41787694..41789895)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41616256..41618460)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41755432..41757633)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17194 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41755120-41756119 Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene Sharpr-MPRA regulatory region 15280 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene small nucleolar RNA SNORA8 Neighboring gene MPRA-validated peak5805 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41861872-41862386 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:41862979-41863271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24529 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:41884515-41885714 Neighboring gene mediator complex subunit 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24530 Neighboring gene bystin like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts. Chassin D, et al. Cancer Res, 1994 Oct 1. PMID 7923143
  2. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Kato H, et al. Biochem Biophys Res Commun, 2008 May 9. PMID 18331822
  3. Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. Gevaert K, et al. Proteomics, 2005 Sep. PMID 16097034
  4. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. Dai FF, et al. J Biol Chem, 2015 Oct 9. PMID 26272612, Free PMC Article
  5. Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner. García-Gutiérrez L, et al. Cell Death Dis, 2022 Aug 8. PMID 35941108, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The human counterparts of Tom5 and Tom6, together with the other components including Tom7, were identified in the preprotein translocase complex.
    Title: Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32622, DKFZp761H221

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein insertion into mitochondrial outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of TOM complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
mitochondrial import receptor subunit TOM6 homolog
Names
over-expressed breast tumor protein
overexpressed breast tumor protein
translocase of outer membrane 6 kDa subunit homolog
translocase of outer mitochondrial membrane 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134493.2 → NP_001127965.1  mitochondrial import receptor subunit TOM6 homolog

    See identical proteins and their annotated locations for NP_001127965.1

    Status: REVIEWED

    Source sequence(s)
    AL365205
    Consensus CDS
    CCDS47424.1
    UniProtKB/Swiss-Prot
    B2DG15, Q96B49, Q9UH52
    Related
    ENSP00000381859.3, ENST00000398884.7
    Conserved Domains (1) summary
    pfam15184
    Location:1 → 74
    TOM6p; Mitochondrial import receptor subunit TOM6 homolog

  2. NM_001382294.1 → NP_001369223.1  mitochondrial import receptor subunit TOM6 homolog

    Status: REVIEWED

    Source sequence(s)
    AL365205
    Consensus CDS
    CCDS47424.1
    UniProtKB/Swiss-Prot
    B2DG15, Q96B49, Q9UH52
    Related
    ENSP00000381856.3, ENST00000398881.4
    Conserved Domains (1) summary
    pfam15184
    Location:1 → 74
    TOM6p; Mitochondrial import receptor subunit TOM6 homolog

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    41787694..41789895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    41616256..41618460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96B49.1 GenPept UniProtKB/Swiss-Prot:Q96B49

Gene LinkOut

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