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INSIG2 insulin induced gene 2 [ Sus scrofa (pig) ]

Gene ID: 100170127, updated on 17-Aug-2024

Summary

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Official Symbol
INSIG2provided by VGNC
Official Full Name
insulin induced gene 2provided by VGNC
Primary source
VGNC:VGNC:103970
See related
Ensembl:ENSSSCG00000036229
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
INSIG-2
Expression
Ubiquitous expression in liver (RPKM 16.9), mixtures (RPKM 10.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See INSIG2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (23676684..23699591)

Chromosome 15 - NC_010457.5Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 5B Neighboring gene coiled-coil domain containing 93 Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene engrailed homeobox 1 Neighboring gene macrophage receptor with collagenous structure

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_010457.5 Chromosome 15 Reference Sscrofa11.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Pig fatness in relation to FASN and INSIG2 genes polymorphism and their transcript level. Grzes M, et al. Mol Biol Rep, 2016 May. PMID 26965892, Free PMC Article
  2. Sequencing and chromosome mapping of pig INSIG 2 and a related pseudogene. Qiu H, et al. Anim Genet, 2005 Apr. PMID 15771747
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FASN gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition
    Title: Pig fatness in relation to FASN and INSIG2 genes polymorphism and their transcript level.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in SREBP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SREBP-SCAP complex retention in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of SREBP-SCAP-Insig complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-induced gene 2 protein
Names
insulin-induced membrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129968.1 → NP_001123440.1  insulin-induced gene 2 protein

    See identical proteins and their annotated locations for NP_001123440.1

    Status: PROVISIONAL

    Source sequence(s)
    AY585269
    UniProtKB/Swiss-Prot
    Q5Y8D7, Q6PQZ3
    UniProtKB/TrEMBL
    A0A0B8S067, A0A8D0MRK7, D2DXL3
    Related
    ENSSSCP00000041204.1, ENSSSCT00000056159.3
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010457.5 Reference Sscrofa11.1 Primary Assembly

    Range
    23676684..23699591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021074564.1 → XP_020930223.1  insulin-induced gene 2 protein isoform X2

    UniProtKB/TrEMBL
    A0A8D1BAN4
    Conserved Domains (1) summary
    pfam07281
    Location:1 → 103
    INSIG; Insulin-induced protein (INSIG)

  2. XM_021074560.1 → XP_020930219.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/Swiss-Prot
    Q5Y8D7, Q6PQZ3
    UniProtKB/TrEMBL
    A0A0B8S067, A0A8D0MRK7, D2DXL3
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  3. XM_021074561.1 → XP_020930220.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/Swiss-Prot
    Q5Y8D7, Q6PQZ3
    UniProtKB/TrEMBL
    A0A0B8S067, A0A8D0MRK7, D2DXL3
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  4. XM_021074559.1 → XP_020930218.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/Swiss-Prot
    Q5Y8D7, Q6PQZ3
    UniProtKB/TrEMBL
    A0A0B8S067, A0A8D0MRK7, D2DXL3
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  5. XM_021074562.1 → XP_020930221.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/Swiss-Prot
    Q5Y8D7, Q6PQZ3
    UniProtKB/TrEMBL
    A0A0B8S067, A0A8D0MRK7, D2DXL3
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  6. XM_021074558.1 → XP_020930217.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/Swiss-Prot
    Q5Y8D7, Q6PQZ3
    UniProtKB/TrEMBL
    A0A0B8S067, A0A8D0MRK7, D2DXL3
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PQZ3.2 GenPept UniProtKB/Swiss-Prot:Q6PQZ3

Gene LinkOut

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