flcn.S folliculin S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: flcn.S
Official Full Name: folliculin S homeolog
Primary source: Xenbase:XB-GENE-1003595
Locus tag: XELAEV_18047796mg
See related: EnsemblRapid:ENSXLAG00005011134
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: flcn
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (106125434..106142057, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (99481686..99498308, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell-cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell proliferation involved in kidney development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of pro-B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
colocalizes_with cell-cell contact zone	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: folliculin S homeolog

NP_001121308.1

EC 2.7.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127836.1 → NP_001121308.1 folliculin S homeolog

See identical proteins and their annotated locations for NP_001121308.1

Status: PROVISIONAL

Source sequence(s)

BC124964

UniProtKB/TrEMBL

A0A974BW55, Q08AX6

Related

ENSXLAP00005032746.1, ENSXLAT00005033538.1

Conserved Domains (2) summary

pfam11704
Location:106 → 264

Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport

pfam16692
Location:349 → 563

Folliculin_C; Folliculin C-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

106125434..106142057 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)