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mib2.L MIB E3 ubiquitin protein ligase 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100158387, updated on 4-Nov-2024

Summary

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Official Symbol
mib2.L
Official Full Name
MIB E3 ubiquitin protein ligase 2 L homeolog
Primary source
Xenbase:XB-GENE-17340510
Locus tag
XELAEV_18035630mg
See related
EnsemblRapid:ENSXLAG00005015770 AllianceGenome:Xenbase:XB-GENE-17340510
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable ubiquitin-protein transferase activity and zinc ion binding activity. Predicted to act upstream of or within Notch signaling pathway and protein ubiquitination. Predicted to be located in cytoplasm. Orthologous to human MIB2 (MIB E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mib2.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
19
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (95754739..95818601, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (85997140..86061361, complement)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 11B L homeolog Neighboring gene uncharacterized LOC121395564 Neighboring gene matrix metallopeptidase 23B L homeolog Neighboring gene Golgi integral membrane protein 4 Neighboring gene uncharacterized LOC108696553 Neighboring gene fibronectin type III domain containing 10 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MIB2-like; uncharacterized protein LOC100158387
Names
mindbomb E3 ubiquitin protein ligase 2 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127831.1 → NP_001121303.1  E3 ubiquitin-protein ligase MIB2-like

    See identical proteins and their annotated locations for NP_001121303.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124957
    UniProtKB/TrEMBL
    Q08AY2
    Related
    ENSXLAP00005046391.1, ENSXLAT00005047495.1
    Conserved Domains (6) summary
    cd00204
    Location:428 → 548
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:434 → 526
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:868 → 911
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:596 → 628
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    95754739..95818601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018224227.2 → XP_018079716.1  uncharacterized protein LOC100158387 isoform X1

    UniProtKB/TrEMBL
    A0A8J0T8T5
    Related
    ENSXLAP00005046380.1, ENSXLAT00005047484.1

  2. XM_018224229.2 → XP_018079718.1  uncharacterized protein LOC100158387 isoform X2

    UniProtKB/TrEMBL
    A0A1L8FM48, A0A974HC98
Nucleotide Protein Strain
Heading Accession and Version

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