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acp2.S acid phosphatase 2, lysosomal S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100158274, updated on 18-Sep-2024

Summary

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Official Symbol
acp2.S
Official Full Name
acid phosphatase 2, lysosomal S homeolog
Primary source
Xenbase:XB-GENE-6253082
Locus tag
XELAEV_18024443mg
See related
EnsemblRapid:ENSXLAG00005021425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
LAP; acp2
Summary
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. [provided by RefSeq, Dec 2017]
Orthologs
human mouse all
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Genomic context

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See acp2.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (12236880..12249452, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (11965933..11978477, complement)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene catalase, gene 2 S homeolog Neighboring gene extensin-like Neighboring gene damage-specific DNA binding protein 2 S homeolog Neighboring gene MAP-kinase activating death domain S homeolog Neighboring gene myosin binding protein C3 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysosome organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysosomal acid phosphatase S homeolog
NP_001121203.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127731.2 → NP_001121203.1  lysosomal acid phosphatase S homeolog precursor

    See identical proteins and their annotated locations for NP_001121203.1

    Status: REVIEWED

    Source sequence(s)
    BC160691, BJ030912, BJ036091, BJ099739, BJ614151, BJ624518, BX854248, CF285133, EB483666, JAGEVR010000041
    UniProtKB/Swiss-Prot
    B1H1P9
    UniProtKB/TrEMBL
    A0A974HLA2
    Related
    ENSXLAP00005062919.1, ENSXLAT00005064371.1
    Conserved Domains (1) summary
    cd07061
    Location:34 → 333
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    12236880..12249452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001357139.1: Suppressed sequence

    Description
    NM_001357139.1: This RefSeq was removed because currently there is insufficient support for stop codon readthrough in this gene.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1H1P9.1 GenPept UniProtKB/Swiss-Prot:B1H1P9

Gene LinkOut

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