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AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase [ Sus scrofa (pig) ]

Gene ID: 100156940, updated on 17-Aug-2024

Summary

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Official Symbol
AGLprovided by VGNC
Official Full Name
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferaseprovided by VGNC
Primary source
VGNC:VGNC:106013
See related
Ensembl:ENSSSCG00000006872
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
GDE
Expression
Biased expression in longissimus dorsi muscle (RPKM 62.3), psoas major muscle (RPKM 60.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See AGL in Genome Data Viewer
Location:
chromosome: 4
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (118186031..118269106, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 4 NC_010446.4 (129759895..129831601, complement)

Chromosome 4 - NC_010446.5Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member A3 Neighboring gene uncharacterized LOC110260374 Neighboring gene ferric chelate reductase 1 Neighboring gene uncharacterized LOC110260438 Neighboring gene palmdelphin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Active site mapping of amylo-alpha-1,6-glucosidase in porcine liver glycogen debranching enzyme using fluorogenic 6-O-alpha-glucosyl-maltooligosaccharides. Yamamoto E, et al. J Biochem, 2007 May. PMID 17317688
  2. Activation of 4-alpha-glucanotransferase activity of porcine liver glycogen debranching enzyme with cyclodextrins. Watanabe Y, et al. J Biochem, 2006 Jul. PMID 16798776
  3. Purification of glycogen debranching enzyme from porcine brain: evidence for glycogen catabolism in the brain. Makino Y, et al. Biosci Biotechnol Biochem, 2006 Apr. PMID 16636458
  4. Donor substrate specificity of 4-alpha-glucanotransferase of porcine liver glycogen debranching enzyme and complementary action to glycogen phosphorylase on debranching. Watanabe Y, et al. J Biochem, 2008 Mar. PMID 18174188
  5. SINE indel polymorphism of AGL gene and association with growth and carcass traits in Landrace x Jeju Black pig F(2) population. Han SH, et al. Mol Biol Rep, 2010 Jan. PMID 19649726, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The faster growth rate during the late period and backfat deposition rather than intramuscular fat deposition cause differences in pig productivity according to genotypes of the AGL gene.
    Title: SINE indel polymorphism of AGL gene and association with growth and carcass traits in Landrace x Jeju Black pig F(2) population.
  2. 4-alpha-glucanotransferase action of porcine liver GDE on four 6(4)-O-alpha-maltooligosyl-pyridylamino(PA)-maltooctaoses, in the presence or absence of an acceptor, maltohexaose, was examined.
    Title: Donor substrate specificity of 4-alpha-glucanotransferase of porcine liver glycogen debranching enzyme and complementary action to glycogen phosphorylase on debranching.
  3. The active site accommodates 6(2)-O-alpha-glucosyl-maltohexaose & the interactions of seven glucosyl residues with the active site allow the most rapid hydrolysis of the alpha-1,6-glucosidic linkage of the isomaltosyl moiety.
    Title: Active site mapping of amylo-alpha-1,6-glucosidase in porcine liver glycogen debranching enzyme using fluorogenic 6-O-alpha-glucosyl-maltooligosaccharides.
  4. Glycogen debranching enzyme(GDE)is a polypeptide chain containing distinct active sites for 4-alpha-glucanotransferase & amylo-alpha-1,6-glucosidase activity;debranching of limit dextrin from glycogen carried out by cooperation of the 2 activities
    Title: Activation of 4-alpha-glucanotransferase activity of porcine liver glycogen debranching enzyme with cyclodextrins.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Names
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
amylo-1, 6-glucosidase, 4-alpha-glucanotransferase
glycogen debranching enzyme
glycogen storage disease type III

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010446.5 Reference Sscrofa11.1 Primary Assembly

    Range
    118186031..118269106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002343732.1 RNA Sequence

    Related
    ENSSSCT00000007525.5

  2. XR_002343731.1 RNA Sequence

  3. XR_002343734.1 RNA Sequence

  4. XR_002343733.1 RNA Sequence

    Related
    ENSSSCT00000063944.3
Nucleotide Protein
Heading Accession and Version

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