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PTEN phosphatase and tensin homolog [ Sus scrofa (pig) ]

Gene ID: 100156264, updated on 17-Aug-2024

Summary

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Official Symbol
PTENprovided by VGNC
Official Full Name
phosphatase and tensin homologprovided by VGNC
Primary source
VGNC:VGNC:111132
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in lung (RPKM 36.2), spleen (RPKM 36.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See PTEN in Genome Data Viewer
Location:
chromosome: 14
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (99929590..100021619)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (108911519..109003081)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102162281 Neighboring gene killin, p53 regulated DNA replication inhibitor Neighboring gene renalase, FAD dependent amine oxidase Neighboring gene uncharacterized LOC110256749

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTEN and PMAIP1 are targets of miR-26a-5p and let-7g-5p, respectively.
    Title: Testosterone-Dependent miR-26a-5p and let-7g-5p Act as Signaling Mediators to Regulate Sperm Apoptosis via Targeting PTEN and PMAIP1.
  2. PTEN/Akt signaling pathway contributes to cardiomyocyte apoptosis after coronary microembolization.
    Title: The PTEN/Akt Signaling Pathway Mediates Myocardial Apoptosis in Swine After Coronary Microembolization.
  3. Data suggest the development of phosphatase and tensin homolog deleted on chromosome ten (PTEN)-based anti-inflammatory strategies.
    Title: The involvement of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in the regulation of inflammation following coronary microembolization.
  4. PTEN, FOXO3A and PKB were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
    Title: Formation of primordial follicles and immunolocalization of PTEN, PKB and FOXO3A proteins in the ovaries of fetal and neonatal pigs.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Names
mitochondrial PTENalpha
NP_001137168.1
XP_020927655.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143696.1 → NP_001137168.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    See identical proteins and their annotated locations for NP_001137168.1

    Status: PROVISIONAL

    Source sequence(s)
    FJ436380
    UniProtKB/TrEMBL
    A0A8D0JV81, B8XSI6
    Conserved Domains (2) summary
    smart00404
    Location:92 → 183
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:188 → 349
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    99929590..100021619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021071996.1 → XP_020927655.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

    Conserved Domains (2) summary
    pfam10409
    Location:188 → 267
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl25998
    Location:87 → 184
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version

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