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PSAP prosaposin [ Sus scrofa (pig) ]

Gene ID: 100153167, updated on 17-Aug-2024

Summary

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Official Symbol
PSAPprovided by VGNC
Official Full Name
prosaposinprovided by VGNC
Primary source
VGNC:VGNC:109480
See related
Ensembl:ENSSSCG00000010281
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Broad expression in spleen (RPKM 992.8), lung (RPKM 706.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See PSAP in Genome Data Viewer
Location:
chromosome: 14
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (74734185..74820645, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (80625273..80660726, complement)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene cadherin related 23 Neighboring gene chromosome 14 C10orf105 homolog Neighboring gene V-set immunoregulatory receptor Neighboring gene uncharacterized LOC106506033 Neighboring gene carbohydrate sulfotransferase 3 Neighboring gene uncharacterized LOC110256608

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Transcript variants, expression, and polymorphisms of the pig prosaposin gene. Fang M, et al. DNA Cell Biol, 2011 Jul. PMID 21563967
  2. Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy. Matzner U, et al. J Biol Chem, 2009 Apr 3. PMID 19224915, Free PMC Article
  3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
saposin-B-Val
Names
Saposin-B-Val

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198919.1 → NP_001185848.1  saposin-B-Val precursor

    See identical proteins and their annotated locations for NP_001185848.1

    Status: PROVISIONAL

    Source sequence(s)
    HQ245645
    UniProtKB/TrEMBL
    A0A8D2CEL1, E3VVJ2
    Related
    ENSSSCP00000035634.2, ENSSSCT00000062947.3
    Conserved Domains (4) summary
    smart00162
    Location:491 → 524
    SAPA; Saposin/surfactant protein-B A-type DOMAIN
    smart00741
    Location:313 → 388
    SapB; Saposin (B) Domains
    pfam03489
    Location:357 → 388
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:315 → 349
    SapB_1; Saposin-like type B, region 1

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    74734185..74820645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021071890.1 → XP_020927549.1  saposin-B-Val isoform X6

    UniProtKB/TrEMBL
    A0A8D1PZG1
    Conserved Domains (2) summary
    smart00162
    Location:486 → 519
    SAPA; Saposin/surfactant protein-B A-type DOMAIN
    smart00741
    Location:308 → 383
    SapB; Saposin (B) Domains

  2. XM_021071889.1 → XP_020927548.1  saposin-B-Val isoform X5

    UniProtKB/TrEMBL
    A0A8D1LYA8, A0A8D2CEL1
    Related
    ENSSSCP00000010961.3, ENSSSCT00000011253.5
    Conserved Domains (2) summary
    smart00162
    Location:490 → 523
    SAPA; Saposin/surfactant protein-B A-type DOMAIN
    smart00741
    Location:312 → 387
    SapB; Saposin (B) Domains

  3. XM_021071888.1 → XP_020927547.1  saposin-B-Val isoform X4

    UniProtKB/TrEMBL
    A0A8D0YV90, A0A8D1VQF9, E3VVJ1
    Conserved Domains (2) summary
    smart00162
    Location:492 → 525
    SAPA; Saposin/surfactant protein-B A-type DOMAIN
    smart00741
    Location:314 → 389
    SapB; Saposin (B) Domains

  4. XM_005671043.3 → XP_005671100.1  saposin-B-Val isoform X3

    UniProtKB/TrEMBL
    A0A8D0YV90, A0A8D1VQF9, E3VVJ1
    Conserved Domains (4) summary
    smart00162
    Location:493 → 526
    SAPA; Saposin/surfactant protein-B A-type DOMAIN
    smart00741
    Location:315 → 390
    SapB; Saposin (B) Domains
    pfam03489
    Location:359 → 390
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:317 → 351
    SapB_1; Saposin-like type B, region 1

  5. XM_005671042.3 → XP_005671099.1  saposin-B-Val isoform X2

    UniProtKB/TrEMBL
    A0A8D0YV90, A0A8D1VQF9, E3VVJ1
    Conserved Domains (4) summary
    smart00162
    Location:493 → 526
    SAPA; Saposin/surfactant protein-B A-type DOMAIN
    smart00741
    Location:315 → 390
    SapB; Saposin (B) Domains
    pfam03489
    Location:359 → 390
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:317 → 351
    SapB_1; Saposin-like type B, region 1

  6. XM_005671041.3 → XP_005671098.1  saposin-B-Val isoform X1

    UniProtKB/TrEMBL
    A0A8D0XLK9, A0A8D0YV90, A0A8D1VQF9, E3VVJ1
    Conserved Domains (4) summary
    smart00162
    Location:494 → 527
    SAPA; Saposin/surfactant protein-B A-type DOMAIN
    smart00741
    Location:316 → 391
    SapB; Saposin (B) Domains
    pfam03489
    Location:360 → 391
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:318 → 352
    SapB_1; Saposin-like type B, region 1

  7. XM_021071892.1 → XP_020927551.1  saposin-B-Val isoform X7

    UniProtKB/TrEMBL
    A0A8D1VS87
    Conserved Domains (2) summary
    smart00162
    Location:419 → 452
    SAPA; Saposin/surfactant protein-B A-type DOMAIN
    smart00741
    Location:241 → 316
    SapB; Saposin (B) Domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81405.2 GenPept UniProtKB/Swiss-Prot:P81405

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