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PLCG1 phospholipase C gamma 1 [ Sus scrofa (pig) ]

Gene ID: 100152497, updated on 8-Mar-2024

Summary

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Official Symbol
PLCG1provided by VGNC
Official Full Name
phospholipase C gamma 1provided by VGNC
Primary source
VGNC:VGNC:96492
See related
Ensembl:ENSSSCG00000007356
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in ovary (RPKM 8.8), lung (RPKM 8.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See PLCG1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 17 NC_010459.5 (43810003..43844553)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 17 NC_010459.4 (49203540..49238416)

Chromosome 17 - NC_010459.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110257414 Neighboring gene DNA topoisomerase I Neighboring gene uncharacterized LOC110257501 Neighboring gene uncharacterized LOC110257392 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene receptor-binding cancer antigen expressed on SiSo cells pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Tryptophan Ameliorates Barrier Integrity and Alleviates the Inflammatory Response to Enterotoxigenic Escherichia coli K88 Through the CaSR/Rac1/PLC-γ1 Signaling Pathway in Porcine Intestinal Epithelial Cells. Liu G, et al. Front Immunol, 2021. PMID 34745120, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tryptophan Ameliorates Barrier Integrity and Alleviates the Inflammatory Response to Enterotoxigenic Escherichia coli K88 Through the CaSR/Rac1/PLC-gamma1 Signaling Pathway in Porcine Intestinal Epithelial Cells.
    Title: Tryptophan Ameliorates Barrier Integrity and Alleviates the Inflammatory Response to Enterotoxigenic Escherichia coli K88 Through the CaSR/Rac1/PLC-γ1 Signaling Pathway in Porcine Intestinal Epithelial Cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010459.5 Reference Sscrofa11.1 Primary Assembly

    Range
    43810003..43844553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021078388.1 → XP_020934047.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1TLP3, F1SDV6
    Related
    ENSSSCP00000007834.5, ENSSSCT00000008048.5
    Conserved Domains (11) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd15898
    Location:156 → 185
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain
    cl28895
    Location:156 → 306
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  2. XM_021078389.1 → XP_020934048.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

    UniProtKB/TrEMBL
    A0A4X1TLP3
    Conserved Domains (11) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd15898
    Location:156 → 185
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain
    cl28895
    Location:156 → 306
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  3. XM_021078393.1 → XP_020934052.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X4

    UniProtKB/TrEMBL
    A0A4X1TLP3, A0A8D0P3R5
    Conserved Domains (10) summary
    smart00149
    Location:842 → 957
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:975 → 1099
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:207 → 354
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:551 → 653
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:433 → 537
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:679 → 738
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:752 → 821
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd15898
    Location:44 → 73
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl17171
    Location:1 → 39
    PH-like; Pleckstrin homology-like domain
    cl28895
    Location:44 → 194
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  4. XM_021078392.1 → XP_020934051.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3

    UniProtKB/TrEMBL
    A0A287BD27, A0A4X1TLP3, A0A8D1RRL0
    Conserved Domains (10) summary
    smart00149
    Location:842 → 957
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:975 → 1099
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:207 → 354
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:551 → 653
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:433 → 537
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:679 → 738
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:752 → 821
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd15898
    Location:44 → 73
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl17171
    Location:1 → 39
    PH-like; Pleckstrin homology-like domain
    cl28895
    Location:44 → 194
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  5. XM_021078391.1 → XP_020934050.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3

    UniProtKB/TrEMBL
    A0A287BD27, A0A4X1TLP3, A0A8D1RRL0
    Related
    ENSSSCP00000054018.1, ENSSSCT00000045203.3
    Conserved Domains (10) summary
    smart00149
    Location:842 → 957
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:975 → 1099
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:207 → 354
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:551 → 653
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:433 → 537
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:679 → 738
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:752 → 821
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd15898
    Location:44 → 73
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl17171
    Location:1 → 39
    PH-like; Pleckstrin homology-like domain
    cl28895
    Location:44 → 194
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  6. XM_021078390.1 → XP_020934049.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3

    UniProtKB/TrEMBL
    A0A287BD27, A0A4X1TLP3, A0A8D1RRL0
    Conserved Domains (10) summary
    smart00149
    Location:842 → 957
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:975 → 1099
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:207 → 354
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:551 → 653
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:433 → 537
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:679 → 738
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:752 → 821
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd15898
    Location:44 → 73
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl17171
    Location:1 → 39
    PH-like; Pleckstrin homology-like domain
    cl28895
    Location:44 → 194
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  7. XM_021078394.1 → XP_020934053.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X5

    UniProtKB/TrEMBL
    A0A8D0JRX8, A0A8D0P2P3
    Conserved Domains (10) summary
    smart00149
    Location:727 → 842
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:860 → 984
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:92 → 239
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:436 → 538
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:318 → 422
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:564 → 623
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:637 → 706
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd15898
    Location:1 → 35
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl17171
    Location:262 → 296
    PH-like; Pleckstrin homology-like domain
    cl28895
    Location:1 → 79
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
Nucleotide Protein
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