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DST dystonin [ Sus scrofa (pig) ]

Gene ID: 100152205, updated on 8-Mar-2024

Summary

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Gene symbol
DST
Gene description
dystonin
See related
Ensembl:ENSSSCG00000001499
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in kidney (RPKM 16.2), psoas major muscle (RPKM 11.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See DST in Genome Data Viewer
Location:
chromosome: 7
Exon count:
112
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 7 NC_010449.5 (28812423..29300149)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 7 NC_010449.4 (33273626..33751908)

Chromosome 7 - NC_010449.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100522935 Neighboring gene BEN domain containing 6 Neighboring gene collagen type XXI alpha 1 chain Neighboring gene VPS52 subunit of GARP complex Neighboring gene ribosomal protein S18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables keratin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemidesmosome assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intermediate filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in hemidesmosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dystonin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010449.5 Reference Sscrofa11.1 Primary Assembly

    Range
    28812423..29300149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021098565.1 → XP_020954224.1  dystonin isoform X1

    UniProtKB/TrEMBL
    A0A286ZPP2, A0A287A6B6
    Related
    ENSSSCP00000033447.1, ENSSSCT00000055387.3
    Conserved Domains (10) summary
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7391 → 7453
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6569 → 6784
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    pfam02187
    Location:7468 → 7542
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7605 → 7797
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  2. XM_021098572.1 → XP_020954231.1  dystonin isoform X10

    UniProtKB/TrEMBL
    A0A287A6B6
    Conserved Domains (10) summary
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7391 → 7453
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6569 → 6784
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    pfam02187
    Location:7468 → 7542
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7605 → 7760
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  3. XM_021098573.1 → XP_020954232.1  dystonin isoform X11

    UniProtKB/TrEMBL
    A0A8D0Z4C5
    Conserved Domains (10) summary
    smart00243
    Location:7466 → 7544
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7391 → 7453
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6569 → 6784
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7532 → 7736
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  4. XM_021098567.1 → XP_020954226.1  dystonin isoform X3

    UniProtKB/TrEMBL
    A0A287A6B6
    Related
    ENSSSCP00000039415.2, ENSSSCT00000044218.3
    Conserved Domains (10) summary
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7391 → 7453
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6569 → 6784
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    pfam02187
    Location:7468 → 7536
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7599 → 7791
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  5. XM_021098575.1 → XP_020954234.1  dystonin isoform X12

    UniProtKB/TrEMBL
    A0A8D0Z722
    Conserved Domains (10) summary
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7282 → 7344
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6460 → 6675
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    pfam02187
    Location:7359 → 7433
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7496 → 7688
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  6. XM_021098578.1 → XP_020954237.1  dystonin isoform X15

    UniProtKB/TrEMBL
    A0A287AHQ7, A0A8D0Z722
    Related
    ENSSSCP00000043424.2, ENSSSCT00000055959.3
    Conserved Domains (10) summary
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7282 → 7344
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6460 → 6675
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    pfam02187
    Location:7359 → 7433
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7496 → 7651
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  7. XM_021098576.1 → XP_020954235.1  dystonin isoform X13

    UniProtKB/TrEMBL
    A0A8D0Z722
    Conserved Domains (10) summary
    smart00243
    Location:7357 → 7435
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7282 → 7344
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6460 → 6675
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7472 → 7664
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  8. XM_021098579.1 → XP_020954238.1  dystonin isoform X16

    UniProtKB/TrEMBL
    A0A8D0Z722
    Conserved Domains (10) summary
    smart00243
    Location:7357 → 7435
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7282 → 7344
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6460 → 6675
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7423 → 7627
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  9. XM_021098571.1 → XP_020954230.1  dystonin isoform X8

    UniProtKB/TrEMBL
    A0A8D0Z4C5
    Conserved Domains (10) summary
    smart00243
    Location:7466 → 7538
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7391 → 7453
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6569 → 6784
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7575 → 7767
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  10. XM_021098566.1 → XP_020954225.1  dystonin isoform X2

    UniProtKB/TrEMBL
    A0A287A6B6
    Conserved Domains (10) summary
    PHA02664
    Location:2511 → 2637
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1751 → 1782
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7387 → 7449
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6565 → 6780
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1973 → 2013
    Plectin; Plectin repeat
    pfam02187
    Location:7464 → 7538
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3801 → 4586
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7601 → 7793
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  11. XM_021098568.1 → XP_020954227.1  dystonin isoform X4

    UniProtKB/TrEMBL
    A0A287A6B6
    Conserved Domains (10) summary
    PHA02664
    Location:2504 → 2630
    PHA02664; hypothetical protein; Provisional
    smart00250
    Location:1744 → 1775
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7380 → 7442
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6558 → 6773
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1966 → 2006
    Plectin; Plectin repeat
    pfam02187
    Location:7457 → 7531
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3794 → 4579
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27218
    Location:1678 → 1747
    OmpH; Outer membrane protein (OmpH-like)
    cl28033
    Location:7594 → 7786
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  12. XM_021098569.1 → XP_020954228.1  dystonin isoform X5

    UniProtKB/TrEMBL
    A0A8D0YGT2
    Conserved Domains (10) summary
    PHA02664
    Location:2494 → 2620
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:790 → 881
    SPEC; Spectrin repeats
    smart00250
    Location:1734 → 1765
    PLEC; Plectin repeat
    COG5069
    Location:208 → 444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7370 → 7432
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6548 → 6763
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1956 → 1996
    Plectin; Plectin repeat
    pfam02187
    Location:7447 → 7521
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3784 → 4569
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7584 → 7776
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  13. XM_021098570.1 → XP_020954229.1  dystonin isoform X7

    UniProtKB/TrEMBL
    A0A8D0Z4C5
    Conserved Domains (10) summary
    smart00243
    Location:7466 → 7544
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    PHA02664
    Location:2515 → 2641
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    smart00250
    Location:1755 → 1786
    PLEC; Plectin repeat
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7391 → 7453
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6569 → 6784
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1977 → 2017
    Plectin; Plectin repeat
    cl25732
    Location:3805 → 4590
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7581 → 7773
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  14. XM_013977750.2 → XP_013833204.1  dystonin isoform X32

    UniProtKB/TrEMBL
    A0A287ARN2
    Related
    ENSSSCP00000046517.1, ENSSSCT00000051268.3
    Conserved Domains (11) summary
    smart00243
    Location:7433 → 7505
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    PHA02664
    Location:2482 → 2608
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:778 → 869
    SPEC; Spectrin repeats
    smart00250
    Location:1722 → 1753
    PLEC; Plectin repeat
    COG0419
    Location:1173 → 1724
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00014
    Location:214 → 316
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7358 → 7420
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6536 → 6751
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1944 → 1984
    Plectin; Plectin repeat
    pfam13499
    Location:7359 → 7419
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:3989 → 4154
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  15. XM_021098584.1 → XP_020954243.1  dystonin isoform X25

    UniProtKB/TrEMBL
    A0A480MY17
    Conserved Domains (7) summary
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:5322 → 5384
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4500 → 4715
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:5399 → 5473
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:1737 → 2521
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:5536 → 5728
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  16. XM_021098585.1 → XP_020954244.1  dystonin isoform X26

    UniProtKB/TrEMBL
    A0A480MY17
    Conserved Domains (7) summary
    smart00150
    Location:811 → 902
    SPEC; Spectrin repeats
    COG5069
    Location:208 → 465
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:5318 → 5380
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4496 → 4711
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:5395 → 5469
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:1737 → 2517
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:5532 → 5724
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  17. XM_013977745.2 → XP_013833199.1  dystonin isoform X9

    UniProtKB/TrEMBL
    A0A287A0I5, A0A8D0YGT2
    Related
    ENSSSCP00000037255.1, ENSSSCT00000041384.3
    Conserved Domains (11) summary
    PHA02664
    Location:2482 → 2608
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:778 → 869
    SPEC; Spectrin repeats
    smart00250
    Location:1722 → 1753
    PLEC; Plectin repeat
    COG0419
    Location:1173 → 1724
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00014
    Location:214 → 316
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7358 → 7420
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6536 → 6751
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1944 → 1984
    Plectin; Plectin repeat
    pfam02187
    Location:7436 → 7509
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7359 → 7419
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:3989 → 4154
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  18. XM_005665870.2 → XP_005665927.1  dystonin isoform X27

    UniProtKB/TrEMBL
    A0A480MY17
    Conserved Domains (8) summary
    smart00243
    Location:5364 → 5442
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:778 → 869
    SPEC; Spectrin repeats
    COG0419
    Location:1173 → 1820
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00014
    Location:214 → 316
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:5289 → 5351
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4467 → 4682
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13499
    Location:5290 → 5350
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:1920 → 2085
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  19. XM_021098577.1 → XP_020954236.1  dystonin isoform X14

    UniProtKB/TrEMBL
    A0A480R0X9
    Conserved Domains (10) summary
    PHA02664
    Location:2377 → 2503
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:673 → 764
    SPEC; Spectrin repeats
    smart00250
    Location:1617 → 1648
    PLEC; Plectin repeat
    COG5069
    Location:70 → 327
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7253 → 7315
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6431 → 6646
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1839 → 1879
    Plectin; Plectin repeat
    pfam02187
    Location:7330 → 7404
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3667 → 4452
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7467 → 7659
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  20. XM_013977755.1 → XP_013833209.1  dystonin isoform X17

    UniProtKB/TrEMBL
    A0A480R0X9
    Conserved Domains (11) summary
    PHA02664
    Location:2344 → 2470
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:640 → 731
    SPEC; Spectrin repeats
    smart00250
    Location:1584 → 1615
    PLEC; Plectin repeat
    COG0419
    Location:1035 → 1586
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00014
    Location:76 → 178
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7220 → 7282
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6398 → 6613
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1806 → 1846
    Plectin; Plectin repeat
    pfam02187
    Location:7298 → 7371
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7221 → 7281
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:3851 → 4016
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  21. XM_013977756.2 → XP_013833210.1  dystonin isoform X20

    UniProtKB/TrEMBL
    A0A287BAP9, F1RZU8
    Related
    ENSSSCP00000053626.3, ENSSSCT00000053605.3
    Conserved Domains (11) summary
    PHA02664
    Location:2316 → 2442
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:612 → 703
    SPEC; Spectrin repeats
    smart00250
    Location:1556 → 1587
    PLEC; Plectin repeat
    COG0419
    Location:1007 → 1558
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00014
    Location:36 → 150
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7192 → 7254
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6370 → 6585
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1778 → 1818
    Plectin; Plectin repeat
    pfam02187
    Location:7270 → 7343
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7193 → 7253
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:3823 → 3988
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  22. XM_021098580.1 → XP_020954239.1  dystonin isoform X18

    UniProtKB/TrEMBL
    A0A287BAP9, F1RZU8
    Conserved Domains (10) summary
    PHA02664
    Location:2337 → 2463
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:633 → 724
    SPEC; Spectrin repeats
    smart00250
    Location:1577 → 1608
    PLEC; Plectin repeat
    COG5069
    Location:35 → 287
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7213 → 7275
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6391 → 6606
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1799 → 1839
    Plectin; Plectin repeat
    pfam02187
    Location:7290 → 7364
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3627 → 4412
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7427 → 7619
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  23. XM_005665867.2 → XP_005665924.1  dystonin isoform X22

    UniProtKB/TrEMBL
    A0A287BAP9, F1RZU8
    Conserved Domains (11) summary
    PHA02664
    Location:2304 → 2430
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:600 → 691
    SPEC; Spectrin repeats
    smart00250
    Location:1544 → 1575
    PLEC; Plectin repeat
    COG0419
    Location:995 → 1546
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00014
    Location:36 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:7180 → 7242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6358 → 6573
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1766 → 1806
    Plectin; Plectin repeat
    pfam02187
    Location:7258 → 7331
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7181 → 7241
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:3811 → 3976
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  24. XM_005665875.2 → XP_005665932.1  dystonin isoform X28

    UniProtKB/TrEMBL
    A0A480X857
    Conserved Domains (8) summary
    smart00150
    Location:600 → 691
    SPEC; Spectrin repeats
    COG0419
    Location:995 → 1642
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00014
    Location:36 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:5111 → 5173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4289 → 4504
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:5189 → 5262
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:5112 → 5172
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:1742 → 1907
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  25. XM_021098587.1 → XP_020954246.1  dystonin isoform X29

    UniProtKB/TrEMBL
    A0A480X857
    Conserved Domains (7) summary
    smart00150
    Location:600 → 691
    SPEC; Spectrin repeats
    COG5069
    Location:35 → 254
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:5002 → 5064
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4180 → 4395
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:5079 → 5153
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:1526 → 2310
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:5216 → 5371
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  26. XM_021098582.1 → XP_020954241.1  dystonin isoform X21

    UniProtKB/TrEMBL
    A0A287BAP9, F1RZU8
    Conserved Domains (10) summary
    PHA02664
    Location:2288 → 2414
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:584 → 675
    SPEC; Spectrin repeats
    smart00250
    Location:1528 → 1559
    PLEC; Plectin repeat
    COG5069
    Location:5 → 238
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7164 → 7226
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6342 → 6557
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1750 → 1790
    Plectin; Plectin repeat
    pfam02187
    Location:7241 → 7315
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3578 → 4363
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7378 → 7570
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  27. XM_021098583.1 → XP_020954242.1  dystonin isoform X23

    UniProtKB/TrEMBL
    A0A287BAP9, F1RZU8
    Conserved Domains (10) summary
    PHA02664
    Location:2255 → 2381
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:551 → 642
    SPEC; Spectrin repeats
    smart00250
    Location:1495 → 1526
    PLEC; Plectin repeat
    COG5069
    Location:5 → 205
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7131 → 7193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6309 → 6524
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1717 → 1757
    Plectin; Plectin repeat
    pfam02187
    Location:7208 → 7282
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3545 → 4330
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7345 → 7537
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  28. XM_021098581.1 → XP_020954240.1  dystonin isoform X19

    UniProtKB/TrEMBL
    A0A287BAP9, F1RZU8
    Conserved Domains (10) summary
    PHA02664
    Location:2330 → 2456
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:626 → 717
    SPEC; Spectrin repeats
    smart00250
    Location:1570 → 1601
    PLEC; Plectin repeat
    COG5069
    Location:28 → 280
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:7206 → 7268
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6384 → 6599
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1792 → 1832
    Plectin; Plectin repeat
    pfam02187
    Location:7283 → 7357
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25732
    Location:3620 → 4405
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7420 → 7612
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  29. XM_013977757.2 → XP_013833211.2  dystonin isoform X6

    UniProtKB/TrEMBL
    A0A287A2M3
    Related
    ENSSSCP00000038187.2, ENSSSCT00000061305.3
    Conserved Domains (10) summary
    PHA02664
    Location:2492 → 2618
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:788 → 879
    SPEC; Spectrin repeats
    smart00250
    Location:1732 → 1763
    PLEC; Plectin repeat
    cd00014
    Location:340 → 443
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6546 → 6761
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1954 → 1994
    Plectin; Plectin repeat
    pfam02187
    Location:7445 → 7519
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:7366 → 7429
    EF-hand_7; EF-hand domain pair
    cl25732
    Location:3782 → 4567
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:7582 → 7774
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  30. XM_013977759.2 → XP_013833213.1  dystonin isoform X24

    UniProtKB/TrEMBL
    A0A287B9J3
    Related
    ENSSSCP00000052999.2, ENSSSCT00000061452.3
    Conserved Domains (10) summary
    PHA02664
    Location:1978 → 2104
    PHA02664; hypothetical protein; Provisional
    smart00150
    Location:274 → 365
    SPEC; Spectrin repeats
    smart00250
    Location:1218 → 1249
    PLEC; Plectin repeat
    COG0419
    Location:669 → 1220
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:6854 → 6916
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:6032 → 6247
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:1440 → 1480
    Plectin; Plectin repeat
    pfam02187
    Location:6932 → 7005
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:6855 → 6915
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:3485 → 3650
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  31. XM_005665878.3 → XP_005665935.1  dystonin isoform X31

    Conserved Domains (9) summary
    smart00150
    Location:274 → 365
    SPEC; Spectrin repeats
    smart00250
    Location:2416 → 2449
    PLEC; Plectin repeat
    COG0419
    Location:669 → 1308
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG4942
    Location:1612 → 1898
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:367 → 545
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00261
    Location:1186 → 1462
    Tropomyosin; Tropomyosin
    pfam00681
    Location:2451 → 2490
    Plectin; Plectin repeat
    cl02488
    Location:860 → 1024
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl23720
    Location:1175 → 1288
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  32. XM_003128338.4 → XP_003128386.1  dystonin isoform X30

    UniProtKB/TrEMBL
    A0A480X857
    Conserved Domains (7) summary
    smart00150
    Location:274 → 365
    SPEC; Spectrin repeats
    COG0419
    Location:669 → 1316
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00051
    Location:4785 → 4847
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:3963 → 4178
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:4863 → 4936
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:4786 → 4846
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:1416 → 1581
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Nucleotide Protein
Heading Accession and Version

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