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L2HGDH L-2-hydroxyglutarate dehydrogenase [ Sus scrofa (pig) ]

Gene ID: 100152180, updated on 17-Aug-2024

Summary

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Official Symbol
L2HGDHprovided by VGNC
Official Full Name
L-2-hydroxyglutarate dehydrogenaseprovided by VGNC
Primary source
VGNC:VGNC:89611
See related
Ensembl:ENSSSCG00000005016
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in kidney (RPKM 10.2), psoas major muscle (RPKM 8.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See L2HGDH in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (180020862..180069168, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (200362054..200410286, complement)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene valosin containing protein lysine methyltransferase Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene histone PARylation factor 1 pseudogene Neighboring gene distal membrane arm assembly component 2 like Neighboring gene cyclin dependent kinase like 1 Neighboring gene uncharacterized LOC110262144 Neighboring gene uncharacterized LOC110262146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables (S)-2-hydroxy-acid oxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 2-hydroxyglutarate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
L-2-hydroxyglutarate dehydrogenase, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    180020862..180069168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001926818.5 → XP_001926853.1  L-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8D0Y2N7, A0A8D1FJQ1
    Related
    ENSSSCP00000005394.3, ENSSSCT00000005532.4
    Conserved Domains (2) summary
    PRK11728
    Location:61 → 457
    PRK11728; hydroxyglutarate oxidase; Provisional
    cl21454
    Location:5 → 448
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_021101450.1 → XP_020957109.1  L-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A4X1SGB2, A0A5G2QW07, A0A8D0N9A8
    Related
    ENSSSCP00000066108.2, ENSSSCT00000079344.2
    Conserved Domains (1) summary
    cl26293
    Location:61 → 398
    DAO; FAD dependent oxidoreductase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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