ninj1 ninjurin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ninj1provided by ZNC
Official Full Name: ninjurin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-141216-96
See related: Ensembl:ENSDARG00000103663 AllianceGenome:ZFIN:ZDB-GENE-141216-96
Gene type: protein coding
RefSeq status: INFERRED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch1073-278o19.1
Summary: Predicted to enable cell adhesion mediator activity; lipopolysaccharide binding activity; and membrane destabilizing activity. Involved in muscle cell differentiation. Acts upstream of or within heart development and skeletal muscle tissue development. Predicted to be located in synaptic membrane. Predicted to be active in plasma membrane. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (37102058..37132539, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (36834515..36853425, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We assessed the physiological role of ninjurin1 in zebrafish during heart and skeletal muscle development...Reduced levels of ninjurin1 impaired cardiac and skeletal muscle development in zebrafish
Title: Ninjurin1 regulates striated muscle growth and differentiation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cell adhesion mediator activity	ISS Inferred from Sequence or Structural Similarity more info
enables lipopolysaccharide binding	ISS Inferred from Sequence or Structural Similarity more info
enables membrane destabilizing activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular hyperosmotic response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ferroptosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in leukocyte chemotaxis involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue regeneration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ninjurin-1

Names: nerve injury-induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424064.1 → NP_001410993.1 ninjurin-1

Status: INFERRED

Source sequence(s)

BX248521, CU914619

UniProtKB/Swiss-Prot

A0A0R4IDX9

Related

ENSDARP00000130916.1, ENSDART00000172074.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007122.7 Reference GRCz11 Primary Assembly

Range

37102058..37132539 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479883.2 → XP_021335558.1 ninjurin-1 isoform X1

UniProtKB/TrEMBL

A0A8M9Q7T5

Conserved Domains (1) summary

pfam04923
Location:51 → 137

Ninjurin