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iqsec1b IQ motif and Sec7 domain ArfGEF 1b [ Danio rerio (zebrafish) ]

Gene ID: 100148736, updated on 2-Nov-2024

Summary

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Official Symbol
iqsec1bprovided by ZNC
Official Full Name
IQ motif and Sec7 domain ArfGEF 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120813-1
See related
Ensembl:ENSDARG00000016551 AllianceGenome:ZFIN:ZDB-GENE-120813-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
iqsec1; si:dkey-57n24.7
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within angiogenesis and lymphangiogenesis. Predicted to be located in cytoplasm. Is expressed in liver. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities and lung adenocarcinoma. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See iqsec1b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (26704180..27057252, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (26466564..26819625, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 92 (putative) Neighboring gene acyl-CoA dehydrogenase family, member 9 Neighboring gene histone deacetylase 11 Neighboring gene fibulin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. Manavski Y, et al. Basic Res Cardiol, 2014 Mar. PMID 24522833
  2. The Role of ARF6 in Biliary Atresia. Ningappa M, et al. PLoS One, 2015. PMID 26379158, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasculature development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IQ motif and SEC7 domain-containing protein 1
Names
IQ motif and Sec7 domain 1
IQ motif and Sec7 domain 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    26704180..27057252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224349.1 → XP_068080450.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

  2. XM_009306070.4 → XP_009304345.1  IQ motif and SEC7 domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3BDQ3
    Conserved Domains (4) summary
    cd13318
    Location:832 → 962
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:607 → 795
    Sec7; Sec7 domain
    pfam07052
    Location:949 → 1003
    Hep_59; Hepatocellular carcinoma-associated antigen 59
    pfam14920
    Location:992 → 1090
    MTBP_C; MDM2-binding

  3. XM_009306073.4 → XP_009304348.1  IQ motif and SEC7 domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8M3B6X9
    Conserved Domains (3) summary
    cd13318
    Location:868 → 998
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:643 → 831
    Sec7; Sec7 domain
    pfam07052
    Location:985 → 1039
    Hep_59; Hepatocellular carcinoma-associated antigen 59

  4. XM_005169333.5 → XP_005169390.2  IQ motif and SEC7 domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BGN3, E7EZE5
    Related
    ENSDARP00000043090.6, ENSDART00000043091.8
    Conserved Domains (4) summary
    cd13318
    Location:868 → 998
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:643 → 831
    Sec7; Sec7 domain
    pfam07052
    Location:985 → 1039
    Hep_59; Hepatocellular carcinoma-associated antigen 59
    pfam14920
    Location:1028 → 1126
    MTBP_C; MDM2-binding

  5. XM_009306072.4 → XP_009304347.1  IQ motif and SEC7 domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AXM6
    Conserved Domains (4) summary
    cd13318
    Location:732 → 862
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:507 → 695
    Sec7; Sec7 domain
    pfam07052
    Location:849 → 903
    Hep_59; Hepatocellular carcinoma-associated antigen 59
    pfam14920
    Location:892 → 990
    MTBP_C; MDM2-binding

  6. XM_005169329.5 → XP_005169386.1  IQ motif and SEC7 domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BH76, X1WBR0
    Related
    ENSDARP00000127652.2, ENSDART00000153519.3
    Conserved Domains (4) summary
    cd13318
    Location:750 → 880
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:525 → 713
    Sec7; Sec7 domain
    pfam07052
    Location:867 → 921
    Hep_59; Hepatocellular carcinoma-associated antigen 59
    pfam14920
    Location:910 → 1008
    MTBP_C; MDM2-binding

  7. XM_068224348.1 → XP_068080449.1  IQ motif and SEC7 domain-containing protein 1 isoform X5

  8. XM_068224350.1 → XP_068080451.1  IQ motif and SEC7 domain-containing protein 1 isoform X10

  9. XM_021479852.2 → XP_021335527.1  IQ motif and SEC7 domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8M9PVJ2
    Conserved Domains (3) summary
    pfam01369
    Location:406 → 594
    Sec7; Sec7 domain
    pfam16453
    Location:627 → 756
    IQ_SEC7_PH; PH domain
    cl25574
    Location:736 → 886
    TOP2c; TopoisomeraseII

  10. XM_005169331.5 → XP_005169388.1  IQ motif and SEC7 domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M2BGL8
    Conserved Domains (4) summary
    cd13318
    Location:737 → 867
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:512 → 700
    Sec7; Sec7 domain
    pfam07052
    Location:854 → 908
    Hep_59; Hepatocellular carcinoma-associated antigen 59
    pfam14920
    Location:897 → 995
    MTBP_C; MDM2-binding

  11. XM_005169332.5 → XP_005169389.1  IQ motif and SEC7 domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8M9PVJ2
    Conserved Domains (3) summary
    pfam01369
    Location:406 → 594
    Sec7; Sec7 domain
    pfam16453
    Location:627 → 756
    IQ_SEC7_PH; PH domain
    cl25574
    Location:736 → 886
    TOP2c; TopoisomeraseII

  12. XM_005169330.5 → XP_005169387.1  IQ motif and SEC7 domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BGL9
    Conserved Domains (4) summary
    cd13318
    Location:744 → 874
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:519 → 707
    Sec7; Sec7 domain
    pfam07052
    Location:861 → 915
    Hep_59; Hepatocellular carcinoma-associated antigen 59
    pfam14920
    Location:904 → 1002
    MTBP_C; MDM2-binding
Nucleotide Protein Strain
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