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pgap1 post-GPI attachment to proteins inositol deacylase 1 [ Danio rerio (zebrafish) ]

Gene ID: 100147850, updated on 18-Sep-2024

Summary

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Official Symbol
pgap1provided by ZNC
Official Full Name
post-GPI attachment to proteins inositol deacylase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-090313-216
See related
Ensembl:ENSDARG00000062465 AllianceGenome:ZFIN:ZDB-GENE-090313-216
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-191g15.7
Summary
Predicted to enable phosphatidylinositol deacylase activity. Predicted to be involved in GPI anchor metabolic process and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human PGAP1 (post-GPI attachment to proteins inositol deacylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pgap1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (24126110..24147376)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (24315190..24336748)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene tRNA-yW synthesizing protein 5 Neighboring gene matrix AAA peptidase interacting protein 1 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a Neighboring gene serine/threonine kinase 17b (apoptosis-inducing)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. OTX2 mutations contribute to the otocephaly-dysgnathia complex. Chassaing N, et al. J Med Genet, 2012 Jun. PMID 22577225
  2. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Novarino G, et al. Science, 2014 Jan 31. PMID 24482476, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol deacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI inositol-deacylase
Names
post-GPI attachment to proteins 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    24126110..24147376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478947.2 → XP_021334622.1  GPI inositol-deacylase

    UniProtKB/TrEMBL
    A0A8M9PSV5, F1R8J0
    Related
    ENSDARP00000084779.5, ENSDART00000090346.6
    Conserved Domains (1) summary
    pfam07819
    Location:77 → 298
    PGAP1; PGAP1-like protein

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394753.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    239468..260280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001922397.8 → XP_001922432.2  GPI inositol-deacylase

    UniProtKB/TrEMBL
    A0A8M9PSV5, F1R8J0
    Conserved Domains (1) summary
    pfam07819
    Location:77 → 298
    PGAP1; PGAP1-like protein
Nucleotide Protein Strain
Heading Accession and Version

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