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LIPA lipase A, lysosomal acid type [ Ovis aries (sheep) ]

Gene ID: 100145859, updated on 18-Sep-2024

Summary

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Gene symbol
LIPA
Gene description
lipase A, lysosomal acid type
See related
EnsemblRapid:ENSOARG00020008655
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See LIPA in Genome Data Viewer
Location:
chromosome: 22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 22 NC_056075.1 (10778948..10821072, complement)

Chromosome 22 - NC_056075.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132658442 Neighboring gene Fas cell surface death receptor Neighboring gene cholesterol 25-hydroxylase Neighboring gene DNA fragmentation factor subunit alpha-like Neighboring gene interferon induced protein with tetratricopeptide repeats 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056075.1 Chromosome 22 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables sterol ester esterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in sterol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lysosomal acid lipase/cholesteryl ester hydrolase
Names
lipase A, lysosomal acid, cholesterol esterase
NP_001119818.1
XP_011957824.2
XP_042094376.1
XP_060260383.1
XP_060260384.1
XP_060260385.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126346.1 → NP_001119818.1  lysosomal acid lipase/cholesteryl ester hydrolase precursor

    See identical proteins and their annotated locations for NP_001119818.1

    Status: PROVISIONAL

    Source sequence(s)
    EU579458
    UniProtKB/TrEMBL
    A0A6P9FQE1, B2LSM5, W5Q0F1
    Conserved Domains (3) summary
    pfam00561
    Location:80 → 380
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:37 → 99
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:80 → 246
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056075.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    10778948..10821072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012102434.3 → XP_011957824.2  lysosomal acid lipase/cholesteryl ester hydrolase isoform X2

    UniProtKB/TrEMBL
    W5Q0F1
    Related
    ENSOARP00020043232.1, ENSOART00020068901.1
    Conserved Domains (1) summary
    PLN02872
    Location:38 → 396
    PLN02872; triacylglycerol lipase

  2. XM_042238442.1 → XP_042094376.1  lysosomal acid lipase/cholesteryl ester hydrolase isoform X2

    UniProtKB/TrEMBL
    W5Q0F1
    Conserved Domains (1) summary
    PLN02872
    Location:38 → 396
    PLN02872; triacylglycerol lipase

  3. XM_060404400.1 → XP_060260383.1  lysosomal acid lipase/cholesteryl ester hydrolase isoform X1

  4. XM_060404401.1 → XP_060260384.1  lysosomal acid lipase/cholesteryl ester hydrolase isoform X1

  5. XM_060404402.1 → XP_060260385.1  lysosomal acid lipase/cholesteryl ester hydrolase isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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