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lbr lamin B receptor [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100145693, updated on 4-Nov-2024

Summary

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Official Symbol
lbrprovided by Xenbase
Official Full Name
lamin B receptorprovided by Xenbase
Primary source
Xenbase:XB-GENE-979300
See related
Ensembl:ENSXETG00000018551 AllianceGenome:Xenbase:XB-GENE-979300
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
lmn2r; dhcr14b
Summary
Predicted to enable DNA binding activity and delta14-sterol reductase activity. Predicted to act upstream of or within cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and nuclear inner membrane. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See lbr in Genome Data Viewer
Location:
chromosome: 5
Exon count:
25
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (8563984..8600245)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (4807098..4816199)

Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene signal recognition particle 9kDa Neighboring gene uncharacterized LOC116410903 Neighboring gene ENAH, actin regulator Neighboring gene dynein axonemal heavy chain 14 Neighboring gene cornichon family AMPA receptor auxiliary protein 3 Neighboring gene WD repeat domain 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables delta14-sterol reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
delta(14)-sterol reductase LBR
NP_001120539.1
XP_031757390.1
XP_031757391.1
XP_031757392.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127067.1 → NP_001120539.1  delta(14)-sterol reductase LBR

    See identical proteins and their annotated locations for NP_001120539.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161458
    UniProtKB/TrEMBL
    A0A6I8RR25, B1WAQ1
    Related
    ENSXETP00000087220.2, ENSXETT00000090378.2
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:249 → 618
    PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    8563984..8600245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031901531.1 → XP_031757391.1  delta(14)-sterol reductase LBR isoform X1

    UniProtKB/TrEMBL
    A0A6I8RST4
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:666 → 1069
    PEMT; Phospholipid methyltransferase

  2. XM_031901530.1 → XP_031757390.1  delta(14)-sterol reductase LBR isoform X1

    UniProtKB/TrEMBL
    A0A6I8RST4
    Related
    ENSXETP00000088001.2, ENSXETT00000068637.2
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:666 → 1069
    PEMT; Phospholipid methyltransferase

  3. XM_031901532.1 → XP_031757392.1  delta(14)-sterol reductase LBR isoform X1

    UniProtKB/TrEMBL
    A0A6I8RST4
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:666 → 1069
    PEMT; Phospholipid methyltransferase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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