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IL18 interleukin 18 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100144338, updated on 8-Mar-2024

Summary

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Gene symbol
IL18
Gene description
interleukin 18
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See IL18 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 1 NC_067374.1 (118168494..118187912)

Chromosome 1 - NC_067374.1Genomic Context describing neighboring genes Neighboring gene beta-carotene oxygenase 2 Neighboring gene poly(rC)-binding protein 2-like Neighboring gene testis expressed 12 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene translocase of inner mitochondrial membrane 8 homolog B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067374.1 Chromosome 1 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death. Yoshida T, et al. J Mol Cell Cardiol, 2014 Oct. PMID 25108227, Free PMC Article
  2. Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs. Neves F, et al. Innate Immun, 2015 Nov. PMID 26395994, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pressure overload, while enhancing IL-18 and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 antagonist IL-18BP.
    Title: Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-18
Names
interleukin 18 (interferon-gamma-inducing factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122940.1 → NP_001116412.1  interleukin-18

    See identical proteins and their annotated locations for NP_001116412.1

    Status: PROVISIONAL

    Source sequence(s)
    EU419127
    UniProtKB/TrEMBL
    A0A0N9HP81, A0A0N9HPB8, A0A0N9HRX4, B1A3U4
    Conserved Domains (1) summary
    cl00094
    Location:77 → 178
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067374.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    118168494..118187912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008258602.3 → XP_008256824.1  interleukin-18 isoform X1

    See identical proteins and their annotated locations for XP_008256824.1

    UniProtKB/TrEMBL
    A0A0N9HP81, A0A0N9HPB8, A0A0N9HRX4, B1A3U4
    Conserved Domains (1) summary
    cl00094
    Location:77 → 178
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

  2. XM_008258609.3 → XP_008256831.1  interleukin-18 isoform X2

    UniProtKB/TrEMBL
    A0A5F9CCN1
    Conserved Domains (1) summary
    cl00094
    Location:60 → 161
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
Nucleotide Protein
Heading Accession and Version

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