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GBA2 glucosylceramidase beta 2 [ Bos taurus (domestic cattle) ]

Gene ID: 100139170, updated on 10-Oct-2024

Summary

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Official Symbol
GBA2provided by VGNC
Official Full Name
glucosylceramidase beta 2provided by VGNC
Primary source
VGNC:VGNC:29275
See related
BGD:BT14950; Ensembl:ENSBTAG00000011431
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See GBA2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (59905786..59917185, complement)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-12021 Neighboring gene talin 1 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene RGP1 homolog, RAB6A GEF complex partner 1 Neighboring gene microseminoprotein, prostate associated Neighboring gene natriuretic peptide receptor 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-glucosidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glucosylceramidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucosylceramide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
non-lysosomal glucosylceramidase
Names
glucosidase, beta (bile acid) 2
XP_002689726.1
XP_005210202.1
XP_059745540.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    59905786..59917185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059889557.1 → XP_059745540.1  non-lysosomal glucosylceramidase isoform X3

  2. XM_005210145.5 → XP_005210202.1  non-lysosomal glucosylceramidase isoform X2

    See identical proteins and their annotated locations for XP_005210202.1

    UniProtKB/TrEMBL
    F1MND2
    Conserved Domains (2) summary
    pfam04685
    Location:511 → 854
    DUF608; Protein of unknown function, DUF608
    pfam12215
    Location:156 → 445
    GBA2_N; beta-Glucocerebrosidase 2 N terminal

  3. XM_002689680.7 → XP_002689726.1  non-lysosomal glucosylceramidase isoform X1

    See identical proteins and their annotated locations for XP_002689726.1

    UniProtKB/TrEMBL
    F1MND2
    Related
    ENSBTAP00000015194.3, ENSBTAT00000015194.5
    Conserved Domains (3) summary
    pfam04685
    Location:511 → 876
    DUF608; Protein of unknown function, DUF608
    pfam06202
    Location:609 → 737
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam12215
    Location:156 → 445
    GBA2_N; beta-Glucocerebrosidase 2 N terminal
Nucleotide Protein Strain
Heading Accession and Version

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