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FAM25G family with sequence similarity 25 member G [ Homo sapiens (human) ]

Gene ID: 100133093, updated on 8-Mar-2024

Summary

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Official Symbol
FAM25Gprovided by HGNC
Official Full Name
family with sequence similarity 25 member Gprovided by HGNC
Primary source
HGNC:HGNC:23590
See related
Ensembl:ENSG00000189090 AllianceGenome:HGNC:23590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM25A; FAM25B; FAM25C; bA301J7.4
Expression
Biased expression in skin (RPKM 24.3), esophagus (RPKM 4.4) and 2 other tissues See more
Orthologs
all
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Genomic context

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See FAM25G in Genome Data Viewer
Location:
10q11.22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (47487219..47491700, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (48378520..48383001, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (48247662..48252143)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107001062 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:48324479-48325678 Neighboring gene uncharacterized LOC124902420 Neighboring gene long intergenic non-protein coding RNA 3029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47777655-47778618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:48276917-48277572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47168559-47169492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48257259-48257771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48255153-48256053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48254252-48255152 Neighboring gene BMS1P2-AGAP9 readthrough Neighboring gene annexin A8 Neighboring gene uncharacterized LOC124902421 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA0187

General protein information

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Preferred Names
protein FAM25G
Names
Protein FAM25C
protein FAM25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137549.2 → NP_001131021.1  protein FAM25G

    See identical proteins and their annotated locations for NP_001131021.1

    Status: VALIDATED

    Source sequence(s)
    AL591684
    Consensus CDS
    CCDS73124.1
    UniProtKB/Swiss-Prot
    B2RV02, B3EWG3, B3EWG5, B3EWG6, Q5VTM1
    UniProtKB/TrEMBL
    B7ZW47
    Related
    ENSP00000413896.2, ENST00000452267.2
    Conserved Domains (1) summary
    pfam15825
    Location:24 → 88
    FAM25; FAM25 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    47487219..47491700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    48378520..48383001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B3EWG6.1 GenPept UniProtKB/Swiss-Prot:B3EWG6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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