U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NPIPB5 nuclear pore complex interacting protein family member B5 [ Homo sapiens (human) ]

Gene ID: 100132247, updated on 8-Nov-2023

Summary

Go to the top of the page Help
Official Symbol
NPIPB5provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member B5provided by HGNC
Primary source
HGNC:HGNC:37233
See related
Ensembl:ENSG00000243716 AllianceGenome:HGNC:37233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 35.9), bone marrow (RPKM 26.2) and 24 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16p12.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (22503599..22536535)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (22781607..22814310)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22514920..22547856)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RRN3 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:22458379-22458880 Neighboring gene SMG1 pseudogene 1 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:22510885-22511742 Neighboring gene uncharacterized LOC105371131 Neighboring gene OTOA pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:22585646-22585849 Neighboring gene uncharacterized LOC112268175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:22593503-22594003

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Divergent origins and concerted expansion of two segmental duplications on chromosome 16. Eichler EE, et al. J Hered, 2001 Nov-Dec. PMID 11948212
  2. A proteome-scale map of the SARS-CoV-2-human contactome. Kim DK, et al. Nat Biotechnol, 2023 Jan. PMID 36217029, Free PMC Article
  3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ61599, MGC70907, DKFZp564D113

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear pore complex-interacting protein family member B5
Names
nuclear pore complex interacting protein related

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135865.3 → NP_001129337.1  nuclear pore complex-interacting protein family member B5

    See identical proteins and their annotated locations for NP_001129337.1

    Status: VALIDATED

    Source sequence(s)
    AC106788
    Consensus CDS
    CCDS45443.1
    UniProtKB/Swiss-Prot
    A8MRT5, B4DK13
    Conserved Domains (3) summary
    PHA03307
    Location:871 → 1131
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:46 → 303
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_001395849.1 → NP_001382778.1  nuclear pore complex-interacting protein family member B5

    Status: VALIDATED

    Source sequence(s)
    AC106788
    Consensus CDS
    CCDS45443.1
    UniProtKB/Swiss-Prot
    A8MRT5, B4DK13
    Related
    ENSP00000440703.1, ENST00000424340.7
    Conserved Domains (3) summary
    PHA03307
    Location:871 → 1131
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:46 → 303
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. NM_001395850.1 → NP_001382779.1  nuclear pore complex-interacting protein family member B5

    Status: VALIDATED

    Source sequence(s)
    AC106788
    Consensus CDS
    CCDS45443.1
    UniProtKB/Swiss-Prot
    A8MRT5, B4DK13
    Related
    ENSP00000430633.1, ENST00000517539.5
    Conserved Domains (3) summary
    PHA03307
    Location:871 → 1131
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:46 → 303
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  4. NM_001395851.1 → NP_001382780.1  nuclear pore complex-interacting protein family member B5

    Status: VALIDATED

    Source sequence(s)
    AC106788
    Consensus CDS
    CCDS45443.1
    UniProtKB/Swiss-Prot
    A8MRT5, B4DK13
    Conserved Domains (3) summary
    PHA03307
    Location:871 → 1131
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:46 → 303
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    22503599..22536535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p14 PATCHES

    Range
    568502..601442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    22781607..22814310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MRT5.3 GenPept UniProtKB/Swiss-Prot:A8MRT5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous