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C8orf89 chromosome 8 open reading frame 89 [ Homo sapiens (human) ]

Gene ID: 100130301, updated on 8-Mar-2024

Summary

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Official Symbol
C8orf89provided by HGNC
Official Full Name
chromosome 8 open reading frame 89provided by HGNC
Primary source
HGNC:HGNC:51258
See related
Ensembl:ENSG00000274443 AllianceGenome:HGNC:51258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 2.3), lymph node (RPKM 0.3) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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See C8orf89 in Genome Data Viewer
Location:
8q21.11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (73241331..73285932, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (73670838..73715452, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74153566..74198167, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74085815-74086316 Neighboring gene Sharpr-MPRA regulatory region 10056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74096970-74097470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74097471-74097971 Neighboring gene heat shock protein 90 alpha family class B member 1 pseudogene Neighboring gene uncharacterized LOC105375901 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74152441-74153040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74197691-74198192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74198193-74198692 Neighboring gene peroxiredoxin like 2A pseudogene 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205120-74205828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205829-74206536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74211031-74211531 Neighboring gene NANOG hESC enhancer GRCh37_chr8:74216479-74216980 Neighboring gene ribosomal protein L7 Neighboring gene retinol dehydrogenase 10 Neighboring gene RDH10 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

General protein information

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Preferred Names
putative uncharacterized protein C8orf89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243237.3 → NP_001230166.1  putative uncharacterized protein C8orf89 isoform a

    See identical proteins and their annotated locations for NP_001230166.1

    Status: VALIDATED

    Source sequence(s)
    AC100823
    Consensus CDS
    CCDS75752.1
    UniProtKB/Swiss-Prot
    P0DMQ9
    Related
    ENSP00000485524.1, ENST00000624510.4
    Conserved Domains (1) summary
    pfam17690
    Location:1 → 160
    DUF5537; Family of unknown function (DUF5537)

  2. NM_001391993.1 → NP_001378922.1  putative uncharacterized protein C8orf89 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC100823, AC111149
    Consensus CDS
    CCDS75752.1
    UniProtKB/Swiss-Prot
    P0DMQ9
    Conserved Domains (1) summary
    pfam17690
    Location:1 → 160
    DUF5537; Family of unknown function (DUF5537)

  3. NM_001391994.1 → NP_001378923.1  putative uncharacterized protein C8orf89 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC100823
    Consensus CDS
    CCDS94315.1
    UniProtKB/TrEMBL
    A0A096LNS9
    Related
    ENSP00000485199.1, ENST00000625134.1
    Conserved Domains (1) summary
    pfam17690
    Location:1 → 94
    DUF5537; Family of unknown function (DUF5537)

  4. NM_001391995.1 → NP_001378924.1  putative uncharacterized protein C8orf89 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC100823
    Consensus CDS
    CCDS94316.1
    UniProtKB/TrEMBL
    A0A087WUN2
    Related
    ENSP00000478788.2, ENST00000613105.4
    Conserved Domains (1) summary
    pfam17690
    Location:1 → 71
    DUF5537; Family of unknown function (DUF5537)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    73241331..73285932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421206.1 → XP_047277162.1  putative uncharacterized protein C8orf89 isoform X1

    UniProtKB/TrEMBL
    A0A096LNS9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    73670838..73715452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359514.1 → XP_054215489.1  putative uncharacterized protein C8orf89 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_034020.1: Suppressed sequence

    Description
    NR_034020.1: This RefSeq was permanently suppressed because it is now thought that this gene encodes a protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DMQ9.1 GenPept UniProtKB/Swiss-Prot:P0DMQ9

Gene LinkOut

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