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ZNF730 zinc finger protein 730 [ Homo sapiens (human) ]

Gene ID: 100129543, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF730provided by HGNC
Official Full Name
zinc finger protein 730provided by HGNC
Primary source
HGNC:HGNC:32470
See related
Ensembl:ENSG00000183850 AllianceGenome:HGNC:32470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
19p12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23075211..23147221)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23210338..23282034)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23299827..23330023)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1859 Neighboring gene long intergenic non-protein coding RNA 1858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23257625-23258372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:23260515-23261088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23276545-23277044 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene BCL2 interacting protein 3 pseudogene 37 Neighboring gene sorting nexin 6 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23343199-23343774 Neighboring gene MPRA-validated peak3415 silencer Neighboring gene zinc finger protein 724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14391 Neighboring gene BCL2 interacting protein 3 pseudogene 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10460 Neighboring gene importin 5 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative zinc finger protein 730

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277403.2 → NP_001264332.1  putative zinc finger protein 730

    See identical proteins and their annotated locations for NP_001264332.1

    Status: VALIDATED

    Source sequence(s)
    AC092329, AK131472
    Consensus CDS
    CCDS59371.1
    UniProtKB/Swiss-Prot
    Q6ZMV8
    Related
    ENSP00000472959.1, ENST00000597761.7
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:143 → 498
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:398 → 418
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:270 → 295
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    23075211..23147221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437995.1 → XP_047293951.1  putative zinc finger protein 730 isoform X4

  2. XM_047437996.1 → XP_047293952.1  putative zinc finger protein 730 isoform X4

  3. XM_047437997.1 → XP_047293953.1  putative zinc finger protein 730 isoform X4

  4. XM_047437999.1 → XP_047293955.1  putative zinc finger protein 730 isoform X4

  5. XM_047437998.1 → XP_047293954.1  putative zinc finger protein 730 isoform X4

  6. XM_017026115.3 → XP_016881604.1  putative zinc finger protein 730 isoform X2

  7. XM_047438000.1 → XP_047293956.1  putative zinc finger protein 730 isoform X4

  8. XM_047437994.1 → XP_047293950.1  putative zinc finger protein 730 isoform X4

  9. XM_047438004.1 → XP_047293960.1  putative zinc finger protein 730 isoform X4

  10. XM_047438001.1 → XP_047293957.1  putative zinc finger protein 730 isoform X4

  11. XM_017026114.2 → XP_016881603.1  putative zinc finger protein 730 isoform X1

  12. XM_047438005.1 → XP_047293961.1  putative zinc finger protein 730 isoform X6

  13. XM_047437993.1 → XP_047293949.1  putative zinc finger protein 730 isoform X3

  14. XM_047438002.1 → XP_047293958.1  putative zinc finger protein 730 isoform X5

  15. XM_047438003.1 → XP_047293959.1  putative zinc finger protein 730 isoform X5

RNA

  1. XR_001753564.2 RNA Sequence

  2. XR_001753566.3 RNA Sequence

  3. XR_001753565.2 RNA Sequence

  4. XR_001753568.2 RNA Sequence

  5. XR_007066501.1 RNA Sequence

  6. XR_001753567.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    23210338..23282034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319432.1 → XP_054175407.1  putative zinc finger protein 730 isoform X2

  2. XM_054319434.1 → XP_054175409.1  putative zinc finger protein 730 isoform X7

  3. XM_054319438.1 → XP_054175413.1  putative zinc finger protein 730 isoform X7

  4. XM_054319441.1 → XP_054175416.1  putative zinc finger protein 730 isoform X4

  5. XM_054319436.1 → XP_054175411.1  putative zinc finger protein 730 isoform X7

  6. XM_054319442.1 → XP_054175417.1  putative zinc finger protein 730 isoform X4

  7. XM_054319437.1 → XP_054175412.1  putative zinc finger protein 730 isoform X7

  8. XM_054319440.1 → XP_054175415.1  putative zinc finger protein 730 isoform X7

  9. XM_054319439.1 → XP_054175414.1  putative zinc finger protein 730 isoform X7

  10. XM_054319443.1 → XP_054175418.1  putative zinc finger protein 730 isoform X4

  11. XM_054319435.1 → XP_054175410.1  putative zinc finger protein 730 isoform X7

  12. XM_054319447.1 → XP_054175422.1  putative zinc finger protein 730 isoform X4

  13. XM_054319444.1 → XP_054175419.1  putative zinc finger protein 730 isoform X4

  14. XM_054319431.1 → XP_054175406.1  putative zinc finger protein 730 isoform X1

  15. XM_054319448.1 → XP_054175423.1  putative zinc finger protein 730 isoform X6

  16. XM_054319433.1 → XP_054175408.1  putative zinc finger protein 730 isoform X3

  17. XM_054319445.1 → XP_054175420.1  putative zinc finger protein 730 isoform X5

  18. XM_054319446.1 → XP_054175421.1  putative zinc finger protein 730 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZMV8.1 GenPept UniProtKB/Swiss-Prot:Q6ZMV8

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