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Nudcd3 NudC domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100125378, updated on 10-Oct-2024

Summary

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Symbol
Nudcd3provided by RGD
Full Name
NudC domain containing 3provided by RGD
Primary source
RGD:1642416
See related
EnsemblRapid:ENSRNOG00000056148 AllianceGenome:RGD:1642416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in cilium assembly; protein folding; and protein localization to pericentriolar material. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Orthologous to human NUDCD3 (NudC domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 96.4), Thymus (RPKM 94.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nudcd3 in Genome Data Viewer
Location:
14q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (85190276..85273655, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80976330..81059183, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86326413..86333397, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) Unplaced Scaffold NW_007906770.1 (39982..50084, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352789 Neighboring gene YKT6 v-SNARE homolog Neighboring gene calcium/calmodulin-dependent protein kinase II beta Neighboring gene uncharacterized LOC134481870 Neighboring gene NPC1 like intracellular cholesterol transporter 1 Neighboring gene ribosomal protein L13A, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. knocking down both Ndel1 and NudCL almost blocked retrograde mitochondrial axonal transport.
    Title: Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC125083

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nudC domain-containing protein 3
Names
nudC domain-containing protein 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103362.2 → NP_001096832.1  nudC domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001096832.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2K226, A0A8I6AIG0, Q32PY7
    Related
    ENSRNOP00000072079.2, ENSRNOT00000083191.3
    Conserved Domains (2) summary
    pfam14050
    Location:9 → 67
    Nudc_N; N-terminal conserved domain of Nudc
    cl00175
    Location:186 → 265
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

  2. NM_001419338.1 → NP_001406267.1  nudC domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I5Y9V8, A6IKS1
    Related
    ENSRNOP00000087625.2, ENSRNOT00000112627.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    85190276..85273655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005492870.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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