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Cxcr6 C-X-C motif chemokine receptor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100124593, updated on 2-Nov-2024

Summary

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Official Symbol
Cxcr6provided by RGD
Official Full Name
C-X-C motif chemokine receptor 6provided by RGD
Primary source
RGD:1642118
See related
EnsemblRapid:ENSRNOG00000089617 AllianceGenome:RGD:1642118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chemokine binding activity and chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within chemokine-mediated signaling pathway. Predicted to be active in external side of plasma membrane. Orthologous to human CXCR6 (C-X-C motif chemokine receptor 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See Cxcr6 in Genome Data Viewer
Location:
8q32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (132311834..132317001)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (123434417..123439568)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (132869712..132870766)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 9 Neighboring gene FYVE and coiled-coil domain autophagy adaptor 1 Neighboring gene basic leucine zipper and W2 domains 1, pseudogene 2 Neighboring gene X-C motif chemokine receptor 1 Neighboring gene CDK2-associated, cullin domain 1, pseudogene 1 Neighboring gene transcription initiation factor TFIID subunit 13-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis. Latta M, et al. Immunology, 2007 Aug. PMID 17437534, Free PMC Article
  2. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Matloubian M, et al. Nat Immunol, 2000 Oct. PMID 11017100
  3. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Rabquer BJ, et al. Arthritis Res Ther, 2011 Feb 8. PMID 21303517, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-X-C chemokine binding ISO
Inferred from Sequence Orthology
more info
  
enables C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C-X-C chemokine receptor type 6
Names
chemokine (C-X-C motif) receptor 6
chemokine receptor CXCR6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102587.2 → NP_001096057.1  C-X-C chemokine receptor type 6

    See identical proteins and their annotated locations for NP_001096057.1

    Status: VALIDATED

    Source sequence(s)
    DQ132631, JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A6M4C4C7, A0A6M4C4D9, A0A6M4C4J1, A0A6M4C4K1, A0A6M4C534, A7ISD5
    Conserved Domains (2) summary
    cd14964
    Location:41 → 68
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:41 → 307
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    132311834..132317001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080642.2 → XP_038936570.1  C-X-C chemokine receptor type 6 isoform X1

    UniProtKB/TrEMBL
    A0A6M4C4C7, A0A6M4C4D9, A0A6M4C4J1, A0A6M4C4K1, A0A6M4C534, A6I4C7, F7F415
    Related
    ENSRNOP00000100445.1, ENSRNOT00000124892.1
    Conserved Domains (2) summary
    cd14964
    Location:44 → 71
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:44 → 310
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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