LIG1 DNA ligase 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: LIG1provided by VGNC
Official Full Name: DNA ligase 1provided by VGNC
Primary source: VGNC:VGNC:30882
See related: BGD:BT16412; Ensembl:ENSBTAG00000014595
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (54865681..54892962, complement)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA ligase (ATP) activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info	PubMed
involved_in Okazaki fragment processing involved in mitotic DNA replication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lagging strand elongation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA ligase 1

Names: DNA ligase (ATP) 1; DNA ligase I

NP_001096018.1

EC 6.5.1.1

XP_005219188.2

EC 6.5.1.1

XP_010813282.2

EC 6.5.1.1

XP_010813283.2

EC 6.5.1.1

XP_010813284.2

EC 6.5.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102548.1 → NP_001096018.1 DNA ligase 1

See identical proteins and their annotated locations for NP_001096018.1

Status: PROVISIONAL

Source sequence(s)

BC134518

UniProtKB/TrEMBL

A0AAA9S0X0, A4IFC8, F1MSC6

Related

ENSBTAP00000031866.5, ENSBTAT00000031920.6

Conserved Domains (4) summary

cd07969
Location:751 → 896

OBF_DNA_ligase_I; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit

cd07900
Location:528 → 746

Adenylation_DNA_ligase_I_Euk; Adenylation domain of eukaryotic DNA Ligase I

PLN03113
Location:180 → 913

PLN03113; DNA ligase 1; Provisional

pfam04675
Location:285 → 456

DNA_ligase_A_N; DNA ligase N terminus

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

Range

54865681..54892962 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005219131.5 → XP_005219188.2 DNA ligase 1 isoform X3

UniProtKB/TrEMBL

A0AAA9S0X0

Conserved Domains (2) summary

cl25417
Location:182 → 912

CDC9; ATP-dependent DNA ligase [Replication, recombination and repair]

cl25751
Location:11 → 234

DUF4045; Domain of unknown function (DUF4045)
XM_010814981.4 → XP_010813283.2 DNA ligase 1 isoform X2

UniProtKB/TrEMBL

A0AAA9S0X0

Conserved Domains (2) summary

cl25417
Location:182 → 927

CDC9; ATP-dependent DNA ligase [Replication, recombination and repair]

cl25751
Location:11 → 228

DUF4045; Domain of unknown function (DUF4045)
XM_010814980.4 → XP_010813282.2 DNA ligase 1 isoform X1

UniProtKB/TrEMBL

A0AAA9S0X0

Conserved Domains (2) summary

cl25417
Location:180 → 928

CDC9; ATP-dependent DNA ligase [Replication, recombination and repair]

cl25751
Location:11 → 229

DUF4045; Domain of unknown function (DUF4045)
XM_010814982.4 → XP_010813284.2 DNA ligase 1 isoform X4

UniProtKB/TrEMBL

A0AAA9SFS7

Conserved Domains (2) summary

cl25417
Location:222 → 970

CDC9; ATP-dependent DNA ligase [Replication, recombination and repair]

cl25751
Location:5 → 271

DUF4045; Domain of unknown function (DUF4045)