Mir696 microRNA 696 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Mir696provided by MGI
Official Full Name: microRNA 696provided by MGI
Primary source: MGI:MGI:3718557
See related: miRBase:MI0004677; AllianceGenome:MGI:3718557
Gene type: ncRNA
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn696; mmu-mir-696
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Annotation information: not in current annotation release
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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1alpha inhibition.
Title: The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition.
Study proposes a novel insight that miR-696 down-regulates C2C12 cell myogenesis by inhibiting CNTFRalpha expression.
Title: MiR-696 Regulates C2C12 Cell Proliferation and Differentiation by Targeting CNTFRα.
Data indicate that microRNA miR696 directly recognizes a specific location within the 3'-untranslated region of peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha (PGC-1alpha) transcripts.
Title: miR-696 plays a role in hepatic gluconeogenesis in ob/ob mice by targeting PGC-1α.
miR-494 and miR-696 are sensitive miRNAs in response to exercise training
Title: Voluntary wheel exercise alters the levels of miR-494 and miR-696 in the skeletal muscle of C57BL/6 mice.
miR-696 plays a role in the ectopic deposition of lipids induced by resistin in skeletal muscle at least partially.
Title: Resistin Increases Ectopic Deposition of Lipids Through miR-696 in C2C12 Cells.
These observations demonstrate that miR-696 is a physical activity-dependent miRNA involved in the translational regulation of PGC-1alpha and skeletal muscle metabolism in mice
Title: The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity.

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General gene information

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Other Names

microRNA Mirn696

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid oxidation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to muscle activity	IDA Inferred from Direct Assay more info	PubMed