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IFIH1 interferon induced with helicase C domain 1 [ Sus scrofa (pig) ]

Gene ID: 100101927, updated on 17-Aug-2024

Summary

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Official Symbol
IFIH1provided by VGNC
Official Full Name
interferon induced with helicase C domain 1provided by VGNC
Primary source
VGNC:VGNC:98042
See related
Ensembl:ENSSSCG00000015897
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
MDA5
Expression
Ubiquitous expression in spleen (RPKM 23.9), lung (RPKM 19.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See IFIH1 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (68930998..68985145, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 15 NC_010457.4 (76422958..76477124, complement)

Chromosome 15 - NC_010457.5Genomic Context describing neighboring genes Neighboring gene glucagon Neighboring gene fibroblast activation protein alpha Neighboring gene grancalcin Neighboring gene potassium voltage-gated channel subfamily H member 7 Neighboring gene uncharacterized LOC110257122

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Foot-and-Mouth Disease Virus Evades Innate Immune Response by 3C-Targeting of MDA5. Kim H, et al. Cells, 2021 Jan 29. PMID 33572945, Free PMC Article
  2. Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway. Li LF, et al. J Virol, 2017 Jun 1. PMID 28331099, Free PMC Article
  3. Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-κB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages. Dong XY, et al. Virol J, 2013 Sep 13. PMID 24034559, Free PMC Article
  4. Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs. Kojima-Shibata C, et al. Immunogenetics, 2009 Feb. PMID 19099299
  5. Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C, et al. Science, 2013 Feb 8. PMID 23328395

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Foot-and-Mouth Disease Virus Evades Innate Immune Response by 3C-Targeting of MDA5.
    Title: Foot-and-Mouth Disease Virus Evades Innate Immune Response by 3C-Targeting of MDA5.
  2. study identifies the porcine 2'-5'-oligoadenylate synthetase-like protein (pOASL) as an interferon (IFN)-stimulated gene (ISG) against classical swine fever virus (CSFV); show that pOASL, as an MDA5-interacting protein, is a coactivator of MDA5-mediated IFN induction to exert anti-CSFV actions
    Title: Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway.
  3. These data indicate that classical swine fever virus can be recognized by both RIG-I and MDA5 to initiate the RIG-I signaling pathway to trigger innate defenses against infection.
    Title: Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-κB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages.
  4. crystal structure of the MDA5 ATP-hydrolysis domain in complex with parainfluenzavirus 5 V protein; the V protein unfolded the ATP-hydrolysis domain of MDA5 and recognized a structural motif of MDA5 normally buried in the helicase fold leading to disruption of MDA5 ATP-hydrolysis site and prevention of RNA-bound MDA5 filament formation
    Title: Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.
  5. IFIH1 had only one nonsynonymous SNP in the helicase domain.
    Title: Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interferon-induced helicase C domain-containing protein 1
Names
melanoma differentiation associated protein 5
NP_001093664.1
XP_005671938.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100194.1 → NP_001093664.1  interferon-induced helicase C domain-containing protein 1

    See identical proteins and their annotated locations for NP_001093664.1

    Status: PROVISIONAL

    Source sequence(s)
    EU006039
    UniProtKB/TrEMBL
    A0A8D0MTX9, A0A8D1F3D8, A7LCX1
    Related
    ENSSSCP00000044491.1, ENSSSCT00000061806.3
    Conserved Domains (7) summary
    COG1111
    Location:308 → 870
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd08818
    Location:9 → 100
    CARD_MDA5_r1; Caspase activation and recruitment domain found in MDA5, first repeat
    cd15807
    Location:897 → 1013
    MDA5_C; C-terminal domain of Melanoma differentiation-associated protein 5, a cytoplasmic viral RNA receptor
    cd12090
    Location:547 → 691
    MDA5_ID; Insert domain of MDA5
    pfam00271
    Location:695 → 820
    Helicase_C; Helicase conserved C-terminal domain
    pfam04851
    Location:304 → 490
    ResIII; Type III restriction enzyme, res subunit
    cl14633
    Location:112 → 202
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010457.5 Reference Sscrofa11.1 Primary Assembly

    Range
    68930998..68985145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005671881.3 → XP_005671938.1  interferon-induced helicase C domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A286ZT21, A0A8D0MQ69, A0A8D0ZIB5
    Related
    ENSSSCP00000034792.1, ENSSSCT00000032969.4
    Conserved Domains (7) summary
    COG1111
    Location:261 → 823
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd08818
    Location:9 → 100
    CARD_MDA5_r1; Caspase activation and recruitment domain found in MDA5, first repeat
    cd08819
    Location:112 → 202
    CARD_MDA5_r2; Caspase activation and recruitment domain found in MDA5, second repeat
    cd15807
    Location:850 → 966
    MDA5_C; C-terminal domain of Melanoma differentiation-associated protein 5, a cytoplasmic viral RNA receptor
    cd12090
    Location:500 → 644
    MDA5_ID; Insert domain of MDA5
    pfam00271
    Location:648 → 773
    Helicase_C; Helicase conserved C-terminal domain
    pfam04851
    Location:257 → 443
    ResIII; Type III restriction enzyme, res subunit
Nucleotide Protein
Heading Accession and Version

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