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lrp4 LDL receptor related protein 4 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100101694, updated on 17-Aug-2024

Summary

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Official Symbol
lrp4provided by Xenbase
Official Full Name
LDL receptor related protein 4provided by Xenbase
Primary source
Xenbase:XB-GENE-494512
See related
Ensembl:ENSXETG00000005091
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
lrp10; megf7
Orthologs
human mouse all
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Genomic context

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See lrp4 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
38
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (11384231..11443464, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (82583..110913, complement)

Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene catalase, gene 3 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene provisional ortholog of carboxylesterase 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of neurons IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 4
Names
low density lipoprotein receptor-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    11384231..11443464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031900724.1 → XP_031756584.1  low-density lipoprotein receptor-related protein 4

    UniProtKB/TrEMBL
    A0A6I8R352, A0A8J1JFD7
    Related
    ENSXETP00000011107.5, ENSXETT00000011107.5
    Conserved Domains (7) summary
    smart00135
    Location:605 → 645
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:495 → 534
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:370 → 404
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl18310
    Location:1185 → 1377
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:170 → 205
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:1583 → 1623
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:1413 → 1448
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein Strain
Heading Accession and Version

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