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CASP10 caspase 10 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100101580, updated on 8-Mar-2024

Summary

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Gene symbol
CASP10
Gene description
caspase 10
See related
Ensembl:ENSOCUG00000004510
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human all
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Genomic context

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See CASP10 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 7 NC_067380.1 (31646561..31688459, complement)

Chromosome 7 - NC_067380.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 R2-like Neighboring gene protein MEMO1-like Neighboring gene CASP8 and FADD like apoptosis regulator Neighboring gene serine/arginine repetitive matrix protein 2 Neighboring gene E3 ubiquitin-protein ligase FANCL-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067380.1 Chromosome 7 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire. Eckhart L, et al. Mol Biol Evol, 2008 May. PMID 18281271
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
caspase-10
Names
caspase 10, apoptosis-related cysteine peptidase
NP_001093436.1
XP_008257148.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099966.1 → NP_001093436.1  caspase-10

    See identical proteins and their annotated locations for NP_001093436.1

    Status: PROVISIONAL

    Source sequence(s)
    EF397306
    UniProtKB/TrEMBL
    A5HAU9, G1TTE3
    Related
    ENSOCUP00000020313.3, ENSOCUT00000022904.3
    Conserved Domains (3) summary
    cd00032
    Location:221 → 461
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08814
    Location:109 → 187
    DED_Caspase_10_r2; Death Effector Domain, repeat 2, of Caspase-10
    cl14633
    Location:17 → 96
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067380.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    31646561..31688459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008258926.3 → XP_008257148.1  caspase-10 isoform X1

    See identical proteins and their annotated locations for XP_008257148.1

    UniProtKB/TrEMBL
    A5HAU9, G1TTE3
    Conserved Domains (3) summary
    cd00032
    Location:221 → 461
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08814
    Location:109 → 187
    DED_Caspase_10_r2; Death Effector Domain, repeat 2, of Caspase-10
    cl14633
    Location:17 → 96
    DD; Death Domain Superfamily of protein-protein interaction domains
Nucleotide Protein
Heading Accession and Version

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