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PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [ Ornithorhynchus anatinus (platypus) ]

Gene ID: 100075377, updated on 30-Apr-2024

Summary

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Gene symbol
PIK3C2B
Gene description
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
See related
Ensembl:ENSOANG00000013462
Gene type
protein coding
RefSeq status
MODEL
Organism
Ornithorhynchus anatinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus
Orthologs
human mouse all
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Genomic context

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See PIK3C2B in Genome Data Viewer
Location:
chromosome: 7
Exon count:
34
Annotation release Status Assembly Chr Location
105 current mOrnAna1.pri.v4 (GCF_004115215.2) 7 NC_041734.1 (60642479..60704688, complement)

Chromosome 7 - NC_041734.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114813231 Neighboring gene protein phosphatase 1 regulatory subunit 15B Neighboring gene uncharacterized LOC114813227 Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene transfer RNA lysine (anticodon UUU)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_041734.1 Chromosome 7 Reference mOrnAna1.pri.v4 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ornithorhynchus anatinus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrnAna1.pri.v4 Primary Assembly

Genomic

  1. NC_041734.1 Reference mOrnAna1.pri.v4 Primary Assembly

    Range
    60642479..60704688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029069058.2 → XP_028924891.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A6I8NZU8, F7FB55
    Related
    ENSOANP00000021244.2
    Conserved Domains (6) summary
    cd00895
    Location:993 → 1346
    PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
    cd07290
    Location:1375 → 1483
    PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:628 → 800
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1511 → 1633
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:819 → 987
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    pfam00794
    Location:370 → 472
    PI3K_rbd; PI3-kinase family, ras-binding domain

  2. XM_029069059.1 → XP_028924892.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A6I8NZU8
    Conserved Domains (6) summary
    cd00895
    Location:773 → 1126
    PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
    cd07290
    Location:1155 → 1263
    PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:408 → 580
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1291 → 1413
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:599 → 767
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    pfam00794
    Location:150 → 252
    PI3K_rbd; PI3-kinase family, ras-binding domain
Nucleotide Protein
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