folr folate receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: folrprovided by ZNC
Official Full Name: folate receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070615-23
See related: Ensembl:ENSDARG00000102442 AllianceGenome:ZFIN:ZDB-GENE-070615-23
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:165502
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within type B pancreatic cell differentiation. Predicted to be active in external side of plasma membrane. Is expressed in cloaca; head; heart; and pectoral fin. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to several human genes including FOLR1 (folate receptor alpha); FOLR2 (folate receptor beta); and FOLR3 (folate receptor gamma). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (47342124..47349065)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (46903511..46910452)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes beta-cell differentiation.
Title: Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation.
Results show that the gene zgc:165502 is an orthologue of human Folate Receptor 1 located on chromosome 15 and is expressed globally during cleavage and gastrulation.
Title: Expression and characterization of the zebrafish orthologue of the human FOLR1 gene during embryogenesis.

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General gene information

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Markers

z49813 (e-PCR), detects polymorphism
- UniSTS:238559

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within type B pancreatic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: folate receptor

NP_001092242.1

EC 3.1.3.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.