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PLCG1 phospholipase C gamma 1 [ Equus caballus (horse) ]

Gene ID: 100070545, updated on 17-Aug-2024

Summary

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Official Symbol
PLCG1provided by VGNC
Official Full Name
phospholipase C gamma 1provided by VGNC
Primary source
VGNC:VGNC:21542
See related
Ensembl:ENSECAG00000021031
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See PLCG1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 22 NC_009165.3 (31817301..31852160)

Chromosome 22 - NC_009165.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111770006 Neighboring gene DNA topoisomerase I Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene lipin 3 Neighboring gene elastin microfibril interfacer 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009165.3 Chromosome 22 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009165.3 Reference EquCab3.0 Primary Assembly

    Range
    31817301..31852160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023626567.1 → XP_023482335.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

    UniProtKB/TrEMBL
    A0A3Q2GYA3, A0A9L0S554
    Related
    ENSECAP00000069981.1, ENSECAT00000084141.1
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

  2. XM_023626566.1 → XP_023482334.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2GYA3
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

  3. XM_005604632.3 → XP_005604689.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q2GYA3
    Related
    ENSECAP00000025534.2, ENSECAT00000035098.2
    Conserved Domains (8) summary
    smart00149
    Location:823 → 938
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:956 → 1080
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:188 → 335
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:532 → 634
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:414 → 518
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:660 → 719
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:733 → 802
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cl17171
    Location:358 → 392
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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