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PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [ Equus caballus (horse) ]

Gene ID: 100070251, updated on 17-Aug-2024

Summary

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Official Symbol
PFKFB3provided by VGNC
Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3provided by VGNC
Primary source
VGNC:VGNC:21339
See related
Ensembl:ENSECAG00000012172
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See PFKFB3 in Genome Data Viewer
Location:
chromosome: 29
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 29 NC_009172.3 (28826041..28910500, complement)

Chromosome 29 - NC_009172.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111771207 Neighboring gene uncharacterized LOC111771209 Neighboring gene uncharacterized LOC106782761 Neighboring gene uncharacterized LOC111771249 Neighboring gene RNA binding motif protein 17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009172.3 Chromosome 29 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 6-phosphofructo-2-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fructose 2,6-bisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fructose metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009172.3 Reference EquCab3.0 Primary Assembly

    Range
    28826041..28910500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023632009.1 → XP_023487777.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4

    UniProtKB/TrEMBL
    F6R5F5
    Conserved Domains (2) summary
    pfam01591
    Location:7 → 226
    6PF2K; 6-phosphofructo-2-kinase
    pfam00300
    Location:229 → 415
    His_Phos_1; Histidine phosphatase superfamily (branch 1)

  2. XM_005606944.3 → XP_005607001.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X1

    UniProtKB/TrEMBL
    F6R5F5
    Conserved Domains (2) summary
    pfam00300
    Location:270 → 453
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:48 → 267
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_005606947.3 → XP_005607004.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3

    See identical proteins and their annotated locations for XP_005607004.1

    UniProtKB/TrEMBL
    F6R5F5
    Related
    ENSECAP00000046774.1, ENSECAT00000067105.2
    Conserved Domains (2) summary
    pfam00300
    Location:270 → 453
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:48 → 267
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_005606946.3 → XP_005607003.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2

    See identical proteins and their annotated locations for XP_005607003.1

    UniProtKB/TrEMBL
    F6R5F5
    Related
    ENSECAP00000042237.3, ENSECAT00000054819.3
    Conserved Domains (2) summary
    pfam00300
    Location:270 → 453
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:48 → 267
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_005606945.3 → XP_005607002.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X7

    UniProtKB/TrEMBL
    A0A3Q2HJF3
    Related
    ENSECAP00000032620.2, ENSECAT00000056051.2
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 432
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_023632010.1 → XP_023487778.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2GV94
    Conserved Domains (2) summary
    pfam01591
    Location:25 → 204
    6PF2K; 6-phosphofructo-2-kinase
    pfam00300
    Location:207 → 393
    His_Phos_1; Histidine phosphatase superfamily (branch 1)

  7. XM_001499906.6 → XP_001499956.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X5

    See identical proteins and their annotated locations for XP_001499956.2

    UniProtKB/TrEMBL
    F6R5F5
    Related
    ENSECAP00000033636.3, ENSECAT00000042579.3
    Conserved Domains (2) summary
    pfam00300
    Location:249 → 432
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 246
    6PF2K; 6-phosphofructo-2-kinase
Nucleotide Protein
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