WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [Equus caballus (horse)] - Gene

Summary

Official Symbol: WFIKKN2provided by VGNC
Official Full Name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2provided by VGNC
Primary source: VGNC:VGNC:25030
See related: Ensembl:ENSECAG00000015064
Gene type: protein coding
RefSeq status: MODEL
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	EquCab3.0 (GCF_002863925.1)	11	NC_009154.3 (26510982..26522719)

Chromosome 11 - NC_009154.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_009154.3 Chromosome 11 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables receptor antagonist activity	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transforming growth factor beta binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

NC_009154.3 Reference EquCab3.0 Primary Assembly

Range

26510982..26522719

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_023652770.1 → XP_023508538.1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

Conserved Domains (4) summary

cd05765
Location:131 → 211

Ig_3; Subgroup of the immunoglobulin (Ig) superfamily

cd00104
Location:45 → 81

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd03575
Location:362 → 470

NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...

pfam00014
Location:292 → 343

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
XM_005597493.3 → XP_005597550.2 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

Conserved Domains (4) summary

cd05765
Location:131 → 211

Ig_3; Subgroup of the immunoglobulin (Ig) superfamily

cd00104
Location:45 → 81

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd03575
Location:362 → 470

NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...

pfam00014
Location:292 → 343

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
XM_001499780.4 → XP_001499830.2 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

F7CRY5

Related

ENSECAP00000012699.2, ENSECAT00000015764.3

Conserved Domains (5) summary

cd05765
Location:221 → 301

Ig_3; Subgroup of the immunoglobulin (Ig) superfamily

cd00104
Location:135 → 171

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd03575
Location:452 → 560

NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...

pfam00014
Location:382 → 433

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam00095
Location:39 → 86

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'