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EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 [ Equus caballus (horse) ]

Gene ID: 100069848, updated on 17-Aug-2024

Summary

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Official Symbol
EPS15L1provided by VGNC
Official Full Name
epidermal growth factor receptor pathway substrate 15 like 1provided by VGNC
Primary source
VGNC:VGNC:17636
See related
Ensembl:ENSECAG00000019452
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See EPS15L1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 21 NC_009164.3 (2237429..2330822, complement)

Chromosome 21 - NC_009164.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111769659 Neighboring gene KLF transcription factor 2 Neighboring gene calreticulin 3 Neighboring gene chromosome 21 C19orf44 homolog Neighboring gene calcium homeostasis endoplasmic reticulum protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009164.3 Chromosome 21 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor substrate 15-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009164.3 Reference EquCab3.0 Primary Assembly

    Range
    2237429..2330822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023625368.1 → XP_023481136.1  epidermal growth factor receptor substrate 15-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q2HBS3
    Related
    ENSECAP00000017418.4, ENSECAT00000021166.4
    Conserved Domains (3) summary
    smart00027
    Location:121 → 214
    EH; Eps15 homology domain
    cd00052
    Location:19 → 85
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl25732
    Location:385 → 625
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_005604095.3 → XP_005604152.1  epidermal growth factor receptor substrate 15-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2HBS3
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd00176
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)

  3. XM_005604097.3 → XP_005604154.1  epidermal growth factor receptor substrate 15-like 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2HBS3
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd00176
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)

  4. XM_005604096.3 → XP_005604153.1  epidermal growth factor receptor substrate 15-like 1 isoform X2

    See identical proteins and their annotated locations for XP_005604153.1

    UniProtKB/TrEMBL
    A0A3Q2HBS3
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd00176
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)

  5. XM_005604098.3 → XP_005604155.1  epidermal growth factor receptor substrate 15-like 1 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2HBS3
    Related
    ENSECAP00000031083.1, ENSECAT00000053575.3
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd00176
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)

  6. XM_005604099.3 → XP_005604156.1  epidermal growth factor receptor substrate 15-like 1 isoform X8

    UniProtKB/TrEMBL
    A0A5F5PI05
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)
    cl02488
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  7. XM_014734755.2 → XP_014590241.1  epidermal growth factor receptor substrate 15-like 1 isoform X7

    UniProtKB/TrEMBL
    A0A3Q2HW85
    Related
    ENSECAP00000038669.2, ENSECAT00000036487.3
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd00176
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)

  8. XM_005604100.3 → XP_005604157.1  epidermal growth factor receptor substrate 15-like 1 isoform X9

    See identical proteins and their annotated locations for XP_005604157.1

    UniProtKB/TrEMBL
    A0A5F5PI05
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd00176
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)

  9. XM_014734754.2 → XP_014590240.1  epidermal growth factor receptor substrate 15-like 1 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2HML0
    Related
    ENSECAP00000035967.3, ENSECAT00000032594.3
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd00176
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)

  10. XM_005604102.3 → XP_005604159.1  epidermal growth factor receptor substrate 15-like 1 isoform X12

    See identical proteins and their annotated locations for XP_005604159.1

    UniProtKB/TrEMBL
    A0A5F5PI05
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)
    cl02488
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  11. XM_023625369.1 → XP_023481137.1  epidermal growth factor receptor substrate 15-like 1 isoform X10

    UniProtKB/TrEMBL
    A0A5F5PI05
    Conserved Domains (3) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:31 → 97
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl25732
    Location:397 → 637
    SMC_N; RecF/RecN/SMC N terminal domain

  12. XM_005604101.3 → XP_005604158.1  epidermal growth factor receptor substrate 15-like 1 isoform X11

    See identical proteins and their annotated locations for XP_005604158.1

    UniProtKB/TrEMBL
    A0A5F5PI05
    Related
    ENSECAP00000048130.2, ENSECAT00000067123.2
    Conserved Domains (4) summary
    smart00027
    Location:133 → 226
    EH; Eps15 homology domain
    cd00052
    Location:143 → 208
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd00176
    Location:397 → 584
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13870
    Location:396 → 575
    DUF4201; Domain of unknown function (DUF4201)

RNA

  1. XR_289178.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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