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MASP1 MBL associated serine protease 1 [ Equus caballus (horse) ]

Gene ID: 100068261, updated on 17-Aug-2024

Summary

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Official Symbol
MASP1provided by VGNC
Official Full Name
MBL associated serine protease 1provided by VGNC
Primary source
VGNC:VGNC:19989
See related
Ensembl:ENSECAG00000008259
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See MASP1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 19 NC_009162.3 (27532706..27611463, complement)

Chromosome 19 - NC_009162.3Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L26-like Neighboring gene receptor transporter protein 1 Neighboring gene uncharacterized LOC111769054 Neighboring gene uncharacterized LOC111769055 Neighboring gene receptor transporter protein 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009162.3 Chromosome 19 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation, lectin pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mannan-binding lectin serine protease 1
Names
mannan binding lectin serine peptidase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009162.3 Reference EquCab3.0 Primary Assembly

    Range
    27532706..27611463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023623494.1 → XP_023479262.1  mannan-binding lectin serine protease 1 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2I874
    Related
    ENSECAP00000044190.1, ENSECAT00000048455.2
    Conserved Domains (5) summary
    cd00033
    Location:307 → 369
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:454 → 639
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:191 → 300
    CUB; CUB domain
    pfam14670
    Location:159 → 187
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_001499629.5 → XP_001499679.3  mannan-binding lectin serine protease 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2HA46, A0A3Q2I874
    Related
    ENSECAP00000030888.2, ENSECAT00000040304.3
    Conserved Domains (6) summary
    cd00033
    Location:301 → 363
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:448 → 691
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:449 → 691
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:185 → 294
    CUB; CUB domain
    pfam14670
    Location:153 → 181
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_023623492.1 → XP_023479260.1  mannan-binding lectin serine protease 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q2I874
    Conserved Domains (6) summary
    cd00033
    Location:373 → 438
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:455 → 697
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:191 → 300
    CUB; CUB domain
    pfam00084
    Location:307 → 368
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:159 → 187
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  4. XM_023623493.1 → XP_023479261.1  mannan-binding lectin serine protease 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q2I874
    Conserved Domains (6) summary
    cd00033
    Location:373 → 438
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:455 → 697
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:191 → 300
    CUB; CUB domain
    pfam00084
    Location:307 → 368
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:159 → 187
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  5. XM_023623491.1 → XP_023479259.1  mannan-binding lectin serine protease 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q2I874
    Conserved Domains (6) summary
    cd00033
    Location:373 → 438
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:455 → 697
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:191 → 300
    CUB; CUB domain
    pfam00084
    Location:307 → 368
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:159 → 187
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  6. XM_005601879.3 → XP_005601936.1  mannan-binding lectin serine protease 1 isoform X2

    See identical proteins and their annotated locations for XP_005601936.1

    UniProtKB/TrEMBL
    A0A3Q2LEZ9
    Related
    ENSECAP00000039213.2, ENSECAT00000049044.2
    Conserved Domains (6) summary
    cd00033
    Location:301 → 363
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:449 → 711
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:450 → 711
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:185 → 294
    CUB; CUB domain
    pfam14670
    Location:153 → 181
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  7. XM_023623490.1 → XP_023479258.1  mannan-binding lectin serine protease 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2LEZ9
    Conserved Domains (6) summary
    cd00033
    Location:373 → 438
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:455 → 717
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:191 → 300
    CUB; CUB domain
    pfam00084
    Location:307 → 368
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:159 → 187
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  8. XM_005601880.3 → XP_005601937.1  mannan-binding lectin serine protease 1 isoform X6

    See identical proteins and their annotated locations for XP_005601937.1

    UniProtKB/TrEMBL
    A0A3Q2H9W6
    Related
    ENSECAP00000030798.2, ENSECAT00000048166.2
    Conserved Domains (4) summary
    cd00033
    Location:301 → 363
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:185 → 294
    CUB; CUB domain
    pfam14670
    Location:153 → 181
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

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