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PLCZ1 phospholipase C zeta 1 [ Equus caballus (horse) ]

Gene ID: 100067798, updated on 10-Oct-2024

Summary

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Official Symbol
PLCZ1provided by VGNC
Official Full Name
phospholipase C zeta 1provided by VGNC
Primary source
VGNC:VGNC:21547
See related
Ensembl:ENSECAG00000030749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as
PLCz; PLCzp1; PLCzp3; PLCzp2b; PLCzp4b
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Genomic context

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See PLCZ1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) Unplaced Scaffold NW_019645254.1 (7874..48602, complement)

NW_019645254.1Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 3 Neighboring gene zinc finger MYND domain-containing protein 19 pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_019645254 Unplaced Scaffold Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide association study identifies phospholipase C zeta 1 (PLCz1) as a stallion fertility locus in Hanoverian warmblood horses. Schrimpf R, et al. PLoS One, 2014. PMID 25354211, Free PMC Article
  2. Molecular cloning and characterization of phospholipase C zeta in equine sperm and testis reveals species-specific differences in expression of catalytically active protein. Bedford-Guaus SJ, et al. Biol Reprod, 2011 Jul. PMID 21389344
  3. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Non-coding polymorphisms within PLCz1 were identified as conferring stallion fertility and PLCz1 as candidate locus for male fertility in Hanoverian warmblood.
    Title: Genome-wide association study identifies phospholipase C zeta 1 (PLCz1) as a stallion fertility locus in Hanoverian warmblood horses.
  2. displays higher intrinsic intracellular Ca(2+)-releasing activity than murine PLCZ; expressed in round spermatids as well as the sperm flagellum
    Title: Molecular cloning and characterization of phospholipase C zeta in equine sperm and testis reveals species-specific differences in expression of catalytically active protein.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; phospholipase C zeta 1
Names
phospholipase c zeta protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433487.1 → NP_001420416.1  phospholipase C zeta 1

    Status: VALIDATED

    Source sequence(s)
    PJAA01004068

RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NW_019645254.1 Reference EquCab3.0 Primary Assembly

    Range
    7874..48602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023635181.1 → XP_023490949.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

    UniProtKB/TrEMBL
    A0A5F5PNJ0, A0A9L0T797
    Conserved Domains (2) summary
    cl14615
    Location:102 → 428
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl27705
    Location:19 → 585
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  2. XM_014740533.2 → XP_014596019.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

    UniProtKB/TrEMBL
    A0A0B4KE72
    Conserved Domains (4) summary
    cd15898
    Location:3 → 32
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl14615
    Location:154 → 480
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl27705
    Location:71 → 637
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
    cl28895
    Location:3 → 100
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  3. XM_023635182.1 → XP_023490950.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    UniProtKB/TrEMBL
    A0A0B4KE71, A0A5F5PNJ0, F7BFD4
    Related
    ENSECAP00000033766.1, ENSECAT00000036933.2
    Conserved Domains (2) summary
    cl14615
    Location:50 → 376
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl27705
    Location:3 → 533
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  4. XM_023635183.1 → XP_023490951.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    UniProtKB/TrEMBL
    A0A0B4KE71, A0A5F5PNJ0, F7BFD4
    Conserved Domains (2) summary
    cl14615
    Location:50 → 376
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl27705
    Location:3 → 533
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  5. XM_023635185.1 → XP_023490953.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    UniProtKB/TrEMBL
    A0A0B4KE71, A0A5F5PNJ0, F7BFD4
    Conserved Domains (2) summary
    cl14615
    Location:50 → 376
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl27705
    Location:3 → 533
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  6. XM_023635184.1 → XP_023490952.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

    UniProtKB/TrEMBL
    A0A0B4KE71, A0A5F5PNJ0, F7BFD4
    Conserved Domains (2) summary
    cl14615
    Location:50 → 376
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl27705
    Location:3 → 533
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
Nucleotide Protein
Heading Accession and Version

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