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AGRN agrin [ Equus caballus (horse) ]

Gene ID: 100066334, updated on 17-Aug-2024

Summary

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Official Symbol
AGRNprovided by VGNC
Official Full Name
agrinprovided by VGNC
Primary source
VGNC:VGNC:111030
See related
Ensembl:ENSECAG00000030432
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See AGRN in Genome Data Viewer
Location:
chromosome: 2
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 2 NC_009145.3 (48820135..48854357, complement)

Chromosome 2 - NC_009145.3Genomic Context describing neighboring genes Neighboring gene ring finger protein 223 Neighboring gene tyrosine-protein phosphatase non-receptor type 11 Neighboring gene ISG15 ubiquitin like modifier Neighboring gene hes family bHLH transcription factor 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009145.3 Chromosome 2 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor clustering IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
agrin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009145.3 Reference EquCab3.0 Primary Assembly

    Range
    48820135..48854357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023636086.1 → XP_023491854.1  agrin isoform X6

    UniProtKB/TrEMBL
    A0A3Q2HVN7
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1071 → 1195
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1769 → 1801
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1321 → 1470
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:730 → 772
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1612 → 1747
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1275 → 1305
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  2. XM_023636083.1 → XP_023491851.1  agrin isoform X3

    UniProtKB/TrEMBL
    A0A3Q2I311
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1130 → 1254
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1828 → 1860
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1380 → 1529
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1671 → 1806
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1334 → 1364
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  3. XM_023636082.1 → XP_023491850.1  agrin isoform X2

    UniProtKB/TrEMBL
    A0A3Q2I311
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1136 → 1260
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1830 → 1862
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1386 → 1535
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1677 → 1808
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1340 → 1370
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  4. XM_023636084.1 → XP_023491852.1  agrin isoform X4

    UniProtKB/TrEMBL
    A0A3Q2I311
    Related
    ENSECAP00000040049.1, ENSECAT00000035897.2
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1136 → 1260
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1834 → 1866
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1386 → 1535
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1677 → 1812
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1340 → 1370
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  5. XM_023636081.1 → XP_023491849.1  agrin isoform X1

    UniProtKB/TrEMBL
    A0A3Q2I311
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1136 → 1260
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1834 → 1866
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1386 → 1535
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1677 → 1812
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1340 → 1370
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  6. XM_023636085.1 → XP_023491853.1  agrin isoform X5

    UniProtKB/TrEMBL
    A0A3Q2HLS6, A0A3Q2I311
    Related
    ENSECAP00000034913.1, ENSECAT00000048160.2
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1130 → 1254
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1824 → 1856
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1380 → 1529
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1671 → 1802
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1334 → 1364
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  7. XM_023636087.1 → XP_023491855.1  agrin isoform X7

    UniProtKB/TrEMBL
    A0A3Q2HH68
    Conserved Domains (8) summary
    smart00280
    Location:384 → 429
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1029 → 1153
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1727 → 1759
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:316 → 356
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1279 → 1428
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:688 → 730
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1570 → 1705
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1233 → 1263
    EGF; EGF-like domain

  8. XM_023636088.1 → XP_023491856.1  agrin isoform X8

    UniProtKB/TrEMBL
    A0A3Q2HH68
    Related
    ENSECAP00000033792.3, ENSECAT00000053268.3
    Conserved Domains (8) summary
    smart00280
    Location:384 → 429
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1023 → 1147
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1721 → 1753
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:316 → 356
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1273 → 1422
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:688 → 730
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1564 → 1699
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1227 → 1257
    EGF; EGF-like domain
Nucleotide Protein
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